160503-79-7Relevant articles and documents
PHARMACEUTICAL COMPOSITIONS AND THEIR USES
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Page/Page column 59-60, (2021/07/31)
The present invention relates to pharmaceutical compositions, such as topical compositions, comprising certain imidazo [1,2-b] pyridazine compounds and the pharmaceutically acceptable salts and/or solvates of such compounds. The invention also relates to the processes for the preparation of the pharmaceutical compositions, and the uses of such compositions in treating diseases or conditions associated with tropomyosin-related kinase (Trk) activity. More specifically the invention relates to topical pharmaceutical compositions comprising compounds of Formula (I) or a pharmaceutically acceptable salts and/or solvates thereof, which are useful in inhibiting Trk.
IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES AS TRK INHIBITORS
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Page/Page column 53, (2020/02/14)
The present invention relates to certain imidazo[1,2-b]pyridazine compounds and the pharmaceutically acceptable salts of such compounds. The invention also relates to the processes for the preparation of the compounds, compositions containing the compounds, and the uses of such compounds and salts in treating diseases or conditions associated with tropomyosin-related kinase (Trk), activity. More specifically the invention relates to the compounds and their salts useful as inhibitors of Trk. (I) wherein R1, R2, R3, R4 and R5 are as defined herein.
Rotationally Restricted Mimics of Rigid Molecules: Nonspirocyclic Hydantion Aldose Reductase Inhibitors
Rizzi, James P.,Schnur, Rodney C.,Hutson, Nancy J.,Kraus, Kenneth G.,Kelbaugh, Paul R.
, p. 1208 - 1213 (2007/10/02)
Sorbinil (1), a spirocyclic hydantoin, is a potent inhibitor of the enzyme aldose reductase.Simulation of the rigid spirocyclic ring orientation found in sorbinil was achieved with nonspirocyclic 5-hydantoins and 5-5'-
