120158-06-7

Basic information

• Product Name: tert-butyl (4-methoxybenzoyl)carbamate
• Synonyms: tert-butyl (4-methoxybenzoyl)carbamate
• CAS NO: 120158-06-7
• Molecular Weight: 251.282
• Mol File: 120158-06-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 119-120 °C
• Density: 1.125±0.06 g/cm3(Predicted)
• CAS DataBase Reference: tert-butyl (4-methoxybenzoyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (4-methoxybenzoyl)carbamate(120158-06-7)
• EPA Substance Registry System: tert-butyl (4-methoxybenzoyl)carbamate(120158-06-7)

Safety Data

• Hazardous Substances Data: 120158-06-7(Hazardous Substances Data)

Usage

General Description

Tert-butyl (4-methoxybenzoyl)carbamate is a chemical compound that is commonly used as a protecting group in organic synthesis. It is a derivative of tert-butyl carbamate and 4-methoxybenzoyl chloride, which reacts to form the final product. This protecting group is used to block reactive functional groups during chemical reactions in order to prevent unwanted side reactions or to control regioselectivity. Tert-butyl (4-methoxybenzoyl)carbamate is stable under a wide range of reaction conditions and is easily removed using mild acidic conditions, making it a valuable tool in organic synthesis. Additionally, the presence of the methoxy group in the benzoyl moiety can influence the reactivity and selectivity of the compound in various reactions.

Upstream product

• 4248-19-5 tert-butyl carbazate 
• 769069-45-6 tert-butyl N-chlorocarbamate 
• 73210-14-7 N-chloro-N-sodio-tert-butylcarbamate 
• 123-11-5 4-methoxy-benzaldehyde 
• 120157-94-0 N-(tert-butoxycarbonyl)p-methoxybenzylamine 
• 590-28-3 potassium cyanate 
• 201230-82-2 carbon monoxide 
• 696-62-8 para-iodoanisole 
• 75-65-0 tert-butyl alcohol 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 3883-94-1 2-amino-4'-methoxyacetophenone hydrochloride 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 3424-93-9 4-methoxyphenylacetamide 
• 208345-54-4 (-)-(S)-6-methoxy-3-phenyl-3,4-dihydroisoquinolin-1(2H)-one 

Relevant articles and documents

Investigation of the mechanism of racemization of litronesib in aqueous solution: Unexpected base-catalyzed inversion of a fully substituted carbon chiral center

Mitosis inhibitor (R)-litronesib (LY2523355) is a 1,3,4-thiadiazoline- bearing phenyl and N-(2-ethylamino)ethanesulfonamido-methyl substituents on tetrahedral C5. Chiral instability has been observed at pH 6 and above with the rate of racemization increas

Synthesis of acyl carbamates via four component Pd-catalyzed carbonylative coupling of aryl halides, potassium cyanate, and alcohols

A simple and mild method is demonstrated for assembling acyl carbamates through a base-free four-component Pd-catalyzed carbonylation of aryl halides in the presence of potassium cyanate and alcohols in a two-chamber system. This approach produces a wide range of aryl acyl carbamates in good to excellent yields from the corresponding aryl bromides or iodides with near-stoichiometric carbon monoxide. In addition, the method can be extended to the synthesis of primary amides thereby expanding the usefulness of cyanate as an ammonia equivalent.

A New Method for the Synthesis of Amides from Amines: Ruthenium Tetroxide Oxidation of N-Protected Alkylamines

A simple synthetic method for the preparation of amides from the corresponding primary alkylamines was elaborated using ruthenium tetroxide (RuO4) oxidation as a key step.