1201935-41-2

Basic information

• Product Name: 2-[(2,5-dichloro-4-pyridinyl)amino]-N-(methyloxy)benzamide
• Synonyms: 2-[(2,5-dichloro-4-pyridinyl)amino]-N-(methyloxy)benzamide
• CAS NO: 1201935-41-2
• Molecular Weight: 312.155
• Mol File: 1201935-41-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-[(2,5-dichloro-4-pyridinyl)amino]-N-(methyloxy)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2,5-dichloro-4-pyridinyl)amino]-N-(methyloxy)benzamide(1201935-41-2)
• EPA Substance Registry System: 2-[(2,5-dichloro-4-pyridinyl)amino]-N-(methyloxy)benzamide(1201935-41-2)

Safety Data

• Hazardous Substances Data: 1201935-41-2(Hazardous Substances Data)

Upstream product

• 55934-01-5 2,3,5-trichloropyridine 
• 40928-15-2 2-amino-N-methoxy-benzamide 
• 5344-90-1 2-Aminobenzyl alcohol 
• 118-48-9 isatoic anhydride 
• 593-56-6 N-methoxylamine hydrochloride 
• 67-62-9 O-Methylhydroxylamin 
• 796851-03-1 2,5-dichloro-4-iodo-pyridine 

Downstream Products

• 1201933-78-9 2-({5-Chloro-2-[(1,3-dimethyl-1H-pyrazol-4-yl)-amino]-4-pyridinyl}amino)-N-(methyloxy)benzamide 
• 1224887-17-5 2-({5-chloro-2-[(1-ethyl-4-methyl-1H-pyrazol-5-yl)amino]-4-pyridinyl}amino)-N-(methyloxy)benzamide 
• 1348189-51-4 2-({5-chloro-2-[(1,5-dimethyl-1H-pyrazol-4-yl)amino]-4-pyridinyl}amino)-N-(methyloxy)benzamide 
• 1224887-16-4 2-[(5-chloro-2-{[4-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-N-(methyloxy)benzamide 
• 1224887-18-6 2-[(5-chloro-2-{[4-methyl-1-(2-methylpropyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-N-(methyloxy)benzamide 
• 1224887-19-7 2-[(5-chloro-2-{[3-(hydroxymethyl)-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-N-(methyloxy)benzamide 

Relevant articles and documents

Design, synthesis and biological evaluation of ring-fused pyrazoloamino pyridine/pyrimidine derivatives as potential FAK inhibitors

We report herein the synthesis of novel ring-fused pyrazoloamino pyridine/pyrimidine derivatives as potential FAK inhibitors and the evaluation of pharmaceutical activity against five cancer cell lines (MDA-MB-231, BXPC-3, NCI-H1975, DU145 and 786O). Generally, the majority of compounds displayed strong anti-FAK enzymatic potencies (IC50 1 nM) and could effectively inhibit several class of cancer cell lines within the concentration of 3 μM in comparison with GSK2256098 as a reference. Among them, compound 4o is considered to be the most effective due to high sensitivity in antiproliferation. In culture, 4o could not only inhibit FAK Y397 phosphorylation in MDA-MB-231 cell line, but also trigger apoptosis in a dose-dependent manner. Furthermore, computational docking analysis also suggested that 4o and TAE-226 displayed the similar interaction with FAK kinase domain.

PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK

The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.