120205-56-3Relevant articles and documents
CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF
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Page/Page column 115; 116, (2013/06/05)
The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.
The dolastatins. 19. Synthesis of dolaisoleuine
Pettit,Singh,Srirangam,Hogan-Pierson,Williams
, p. 1796 - 1800 (2007/10/02)
The synthesis of dolaisoleuine as its tert-butyl ester (Dil-OBu(t)), a β- methoxy-γ-amino acid component of dolastatin 10, has been achieved employing as key step an aldol condensation between N-(benzyloxycarbonyl)-N-methyl- (S,S)-isoleucinal and tert-butyl acetate followed by O-methylation. The overall six-step reaction sequence to Dil proved to be convenient for routine preparation of this new amino acid and its stereochemical assignment as (3R,4S,5S)-N,O-dimethylisostatine.
The absolute configuration and synthesis of natural (-)-dolastatin 101
Pettit,Singh,Hogan,Lloyd-Williams,Herald,Burkett,Clewlow
, p. 5463 - 5465 (2007/10/02)
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