120222-86-8

Basic information

• Product Name: 4-chloro-3-methoxy-phenyl isothiocyanate
• Synonyms: 4-chloro-3-methoxy-phenyl isothiocyanate
• CAS NO: 120222-86-8
• Molecular Weight: 199.661
• Mol File: 120222-86-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-chloro-3-methoxy-phenyl isothiocyanate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-3-methoxy-phenyl isothiocyanate(120222-86-8)
• EPA Substance Registry System: 4-chloro-3-methoxy-phenyl isothiocyanate(120222-86-8)

Safety Data

• Hazardous Substances Data: 120222-86-8(Hazardous Substances Data)

Upstream product

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Relevant articles and documents

N-Aryl-N’-ethyleneaminothioureas effectively inhibit acetylcholinesterase 1 from disease-transmitting mosquitoes

Vector control of disease-transmitting mosquitoes by insecticides has a central role in reducing the number of parasitic- and viral infection cases. The currently used insecticides are efficient, but safety concerns and the development of insecticide-resistant mosquito strains warrant the search for alternative compound classes for vector control. Here, we have designed and synthesized thiourea-based compounds as non-covalent inhibitors of acetylcholinesterase 1 (AChE1) from the mosquitoes Anopheles gambiae (An. gambiae) and Aedes aegypti (Ae. aegypti), as well as a naturally occurring resistant-conferring mutant. The N-aryl-N’-ethyleneaminothioureas proved to be inhibitors of AChE1; the most efficient one showed submicromolar potency. Importantly, the inhibitors exhibited selectivity over the human AChE (hAChE), which is desirable for new insecticides. The structure-activity relationship (SAR) analysis of the thioureas revealed that small changes in the chemical structure had a large effect on inhibition capacity. The thioureas showed to have different SAR when inhibiting AChE1 and hAChE, respectively, enabling an investigation of structure-selectivity relationships. Furthermore, insecticidal activity was demonstrated using adult and larvae An. gambiae and Ae. aegypti mosquitoes.