120301-26-0

Basic information

• Product Name: 2-{4-[4-(4-fluorophenyl)piperazin-1-yl]butyl}-1H-isoindole-1,3(2H)-dione
• Synonyms: 2-{4-[4-(4-fluorophenyl)piperazin-1-yl]butyl}-1H-isoindole-1,3(2H)-dione
• CAS NO: 120301-26-0
• Molecular Weight: 381.45
• Mol File: 120301-26-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-{4-[4-(4-fluorophenyl)piperazin-1-yl]butyl}-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{4-[4-(4-fluorophenyl)piperazin-1-yl]butyl}-1H-isoindole-1,3(2H)-dione(120301-26-0)
• EPA Substance Registry System: 2-{4-[4-(4-fluorophenyl)piperazin-1-yl]butyl}-1H-isoindole-1,3(2H)-dione(120301-26-0)

Safety Data

• Hazardous Substances Data: 120301-26-0(Hazardous Substances Data)

Upstream product

• 5394-18-3 2-(4-bromobutyl)isoindoline-1,3-dione 
• 2252-63-3 1-(4-Fluorophenyl)piperazine 
• 1074-82-4 potassium phtalimide 
• 371-40-4 4-fluoroaniline 
• 16141-90-5 p-Fluorophenylpiperazine hydrochloride 
• 352-33-0 1-Chloro-4-fluorobenzene 

Downstream Products

• 24805-99-0 4-[4-(4-fluorophenyl)piperazin-1-yl]butan-1-amine 
• 120301-39-5 (E)-N-{4-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-butyl}-3-phenyl-acrylamide 

Relevant articles and documents

Design, synthesis, and evaluation of bitopic arylpiperazine-phthalimides as selective dopamine D3 receptor agonists

The dopamine D3 receptor (D3R) is a proven therapeutic target for the treatment of neurological and neuropsychiatric disorders. In particular, D3R-selective ligands that can eliminate side effects associated with dopamine D2 receptor (D2R) therapeutics have been validated. However, the high homology in signaling pathways and the sequence similarity between D2R and D3R have rendered the development of D3R-selective ligands challenging. Herein, we designed and synthesized a series of piperazine-phthalimide bitopic ligands based on a fragment-based and molecular docking inspired design. Compound 9i was identified as the most selective D3R ligand among these bitopic ligands. Its selectivity was improved compared to reference compounds 1 and 2 by 9- and 2-fold, respectively, and it was 21-fold more potent than compound 2. Molecular docking demonstrated that the orientation of Leu2.64 and Phe7.39 and the packing at the junction of helices may affect the specificity for D3R over D2R. Functional evaluation revealed that D3R-selective ligand 9i displayed a subpicomolar agonist activity at D3R with a 199-fold increase in potency compared to quinpirole. These results may be useful for the fragment-based design of bitopic compounds as selective D3R ligands.

Benzimidazolone-based selective σ2 receptor ligands: Synthesis and pharmacological evaluation

Sigma receptors (σRs) are considered to be a significant and valid target for developing new medications to address several diseases. Their potential involvement in numerous central nervous system disorders, neuropathic pain, addiction, and cancer has bee

Acrylamide derivatives as antiallergic agents. I. Synthesis and structure-activity relationships of N-[(4-substituted 1-piperazinyl)alkyl]-3-(aryl and heteroaryl)acrylamides

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