1203670-16-9

Basic information

• Product Name: C₁₀₂H₁₂₂Cl₇N₁₃O₃₂
• CAS NO: 1203670-16-9
• Molecular Weight: 2290.33
• Mol File: 1203670-16-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₀₂H₁₂₂Cl₇N₁₃O₃₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀₂H₁₂₂Cl₇N₁₃O₃₂(1203670-16-9)
• EPA Substance Registry System: C₁₀₂H₁₂₂Cl₇N₁₃O₃₂(1203670-16-9)

Safety Data

• Hazardous Substances Data: 1203670-16-9(Hazardous Substances Data)

Upstream product

• 104-12-1 p-chlorphenylisocyanate 
• 241820-92-8 hexa-N-Boc neomycin B 

Relevant articles and documents

Antibacterial activities of aminoglycoside antibiotics-derived cationic amphiphiles. Polyol-modified neomycin B-, Kanamycin A-, Amikacin-, and Neamine-based amphiphiles with potent broad spectrum antibacterial activity

Cationic amphiphiles containing multiple positively charged amino functions define a structurally diverse class of antibacterials with broad-spectrum activity and different modes of action. Oligocationic amphiphiles have been used as antibiotics to treat infections and as antiseptics and disinfectants for decades with little or no occurrence of resistance. We have prepared a novel class of cationic amphiphiles termed aminoglycoside antibiotics-derived amphiphiles in which the polyol scaffold of the aminoglycosides neomycin B, kanamycin A, amikacand neamine has been uniformly decorated with hydrophobic residues in the form of polycarbamates and polyethers. Our results show that the nature of the polyol modification as well as the nature of the aminoglycoside antibiotics has a strong effect on the antibacterial potency. The most potent antibacterials are polyol-modified neomycin B-based amphiphiles containing unsubstituted aromatic rings. These analogues exhibit up to 256-fold enhanced antibacterial activity against resistant strains when compared to neomycin B while retaining most of their activity against neomycin B-susceptible strains.