241820-92-8

Basic information

• Product Name: hexa-N-Boc neomycin B
• Synonyms: hexa-N-Boc neomycin B
• CAS NO: 241820-92-8
• Molecular Weight: 1215.35
• Mol File: 241820-92-8.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: hexa-N-Boc neomycin B(CAS DataBase Reference)
• NIST Chemistry Reference: hexa-N-Boc neomycin B(241820-92-8)
• EPA Substance Registry System: hexa-N-Boc neomycin B(241820-92-8)

Safety Data

• Hazardous Substances Data: 241820-92-8(Hazardous Substances Data)

Upstream product

• 119-04-0 neomycin B 
• 24424-99-5 di-tert-butyl dicarbonate 
• 34619-03-9 tert-butyldicarbonate 
• 4146-30-9 neomycin B trisulfate 
• 25389-98-4 neomycin B sulphate 

Downstream Products

• 241820-93-9 1,3,2′,6′,2?,6?-hexa-N-(tert-butoxycarbonyl)-5″-O-(2,4,6-triisopropylbenzenesulfonyl)-neomycin 
• 933770-21-9 3''',4'''-anhydro-3,2',6',2''',6'''-penta-N-(tert-butoxycarbonyl)-1,6-[N-(tert-butoxycarbonyl)epimino]-1-deamino-6-deoxyneomycin B 
• 875654-73-2 3''',4'''-anhydro-1,3,2',6',2''',6'''-hexa-N-(tert-butoxycarbonyl)-neomycin B 
• 933770-22-0 3''',4'''-anhydro-1,3,2',6',2''',6'''-hexa-N-(tert-butoxycarbonyl)-5''-deoxy-5''-(4-nitrobenzoyl)neomycin 
• 933770-23-1 3'''-azido-1,3,2',6',2''',6'''-hexa-N-(tert-butoxycarbonyl)-3'''-deoxy-neomycin B 
• 1067241-20-6 1,3,2',6',2''',6''-hexa-N-(tert-butoxycarbonyl)-5''-O-(p-methylbenzenesulfonyl)-neomycin 
• 794524-06-4 C₁₀₂H₁₃₆N₆O₂₅ 
• 1203670-16-9 C₁₀₂H₁₂₂Cl₇N₁₃O₃₂ 
• 1203669-95-7 4,3',4',2,53',4'-hepta-O-phenylcarbamoyl-1,3,2',6',2',6'-hexa-N-(tert-butoxycarbonyl)-5-deoxy-neomycin 
• 1292767-01-1 5''-O-triphenylmethyl-1,3,2',6',2''',6'''-hexa-N-(tertbutoxycarbonyl)neomycin B 

Relevant articles and documents

Combining the best in triplex recognition: Synthesis and nucleic acid binding of a BQQ-neomycin conjugate

Synthesis of a BQQ-neomycin conjugate is reported. The conjugate combines two ligands, one known to intercalate triplexes (BQQ) and another known to bind in the triplex groove (neomycin). The conjugate stabilizes T·A·T, as well as mixed base DNA triplex,

Synthesis of nucleobase-neomycin conjugates and evaluation of their DNA binding, cytotoxicities, and antibacterial properties

Neomycin is known to preferentially bind to A-form nucleic acid structures including triplex DNA, DNA and RNA hybrid, and duplex RNA. Tethering a DNA intercalator moiety to the C5” position of the ring III of neomycin is a practical approach to develop po

Pyrene-neomycin conjugate: Dual recognition of a DNA triple helix

We report the synthesis of pyrene-neomycin conjugate and its ability to stabilize DNA/RNA triple helices.

Assisted enzyme replacement therapy

Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the cellular uptake of various therapeutic compounds and treatment modalities using these conjugates.

Methods and compositions related to viral inhibition

Disclosed herein are compounds, compositions and methods related to viral inhibition. In some forms, the compounds, compositions and methods are related to binding RNA.