120379-26-2

Basic information

• Product Name: Benzaldehyde, 2-[(6-phenylhexyl)oxy]-
• CAS NO: 120379-26-2
• Molecular Formula: C19H22O2
• Molecular Weight: 282.382
• Mol File: 120379-26-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 2-[(6-phenylhexyl)oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 2-[(6-phenylhexyl)oxy]-(120379-26-2)
• EPA Substance Registry System: Benzaldehyde, 2-[(6-phenylhexyl)oxy]-(120379-26-2)

Safety Data

• Hazardous Substances Data: 120379-26-2(Hazardous Substances Data)

Upstream product

• 27976-27-8 (6-bromohexyl)benzene 
• 90-02-8 salicylaldehyde 
• 2430-16-2 6-phenyl-1-hexanol 

Relevant articles and documents

LEUKOTRIENE ANTAGONISTS

This invention relates to alkanoic acid compounds having phenyl and heteroarylthio substituents which are useful as leukotriene antagonists, processes for the preparation thereof, and pharmaceutical compositions containing such compounds.This invention also relates to methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.

Leukotriene antagonists

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LEUKOTRIENE ANTAGONIST

The compounds represented by the following structural formula (I) STR1 wherein m is 1 or 2; n is 1, 2 or 3; R' is hydrogen or methyl; R is a radical selected from the group consisting of: STR2 wherein R. sub.1 is C 8 to C 13 alkyl, C 7 to C 12 alkoxy, C 7 to C 12 thioalkyl, C 10 to C 12 1-alkynyl, 11-dodecynyl, 1-trans-dodecenyl, 5-(4-acetyl-3-hydroxy-2-propylphenoxypentoxy, 2(Z), 5(Z)-undecadienyloxy, phenyl-C 4 to C. sub.10 alkyl with the phenyl optionally mono substituted with bromo, chloro, trifluoromethyl, methoxy, methylthio or trifluoromethylthio, phenylthio-C 3 to C 9 alkyl with the phenyl optionally mono substituted with bromo, chloro, trifluoromethyl, methoxy, methylthio or trifluoromethylthio, phenyl-CH. dbd.CH--(CH 2) 2-8, phenyl-C 3 to C 9 alkoxy, trifluoromethyl-C 7 to C 12 alkyl, cyclohexyl-C 4 to C 10 alkyl or STR3 wherein each q is 0, 1, 2 or 3 but the sum of both q's does not exceed 3, and R 2 is hydrogen, bromo, chloro, methyl, trifluoromethyl, hydroxy, methoxy or nitro; or R 1 is hydrogen and R. sub.2 is C 8 to C 13 alkyl, C 7 to C 12 alkoxy, C 7 to C 12 thioalkyl, C 10 to C. sub.12 1-alkynyl, 11-dodecynyl, 1-trans-dodecenyl, 5-(4-acetyl-3-hydroxy-2-propylphenoxy(pentoxy, 2(Z), 5(Z)-undecadienyloxy, phenyl-C 4 to C. sub.10 alkyl with the phenyl optionally mono substituted with bromo, chloro, trifluoromethyl, methoxy, methylthio or trifluoromethylthio, phenylthio-C 3 to C 9 alkyl with the phenyl optionally mono substituted with bromo, chloro, trifluoromethyl, methoxy, methylthio or trifluoromethylthio, phenyl-CH. dbd.CH--(CH 2) 2-8, phenyl-C 3 to C 9 alkoxy, trifluoromethyl-C 7 to C 12 alkyl, cyclohexyl-C 4 to C 10 alkyl or STR4 wherein each q is 0, 1, 2 or 3 but the sum of both q's does not exceed 3, and p is 0 or 1, with the proviso that R is not a thiophene radical and any of R 1 and R. sub.2 above are not thioalkyl or phenylthioalkyl when p is 1; and pharmaceutically acceptable salts thereof have been found to be leukotriene antagonists and useful in the treatment of diseases in which leukotrienes are a factor, such as asthma.