27976-27-8

Basic information

• Product Name: 1-BROMO-6-PHENYLHEXANE
• Synonyms: 1-BROMO-6-PHENYLHEXANE;6-BROMOHEXYL BENZENE;RARECHEM AH CK 0047;6-Phenyl-n-hexyl bromide;1-Bromo-6-phenylhexane 98%;1-BROMO-6-PHENYL-HEXANE >98%;1-Bromo-7-phenylhexane;(6-Bromohexyl)benzol
• CAS NO: 27976-27-8
• Molecular Formula: C₁₂H₁₇Br
• Molecular Weight: 241.17
• Mol File: 27976-27-8.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 115-118°C 6mm
• Flash Point: 115-118°C/6mm
• Appearance: /
• Density: 1.197
• Vapor Pressure: 0.00218mmHg at 25°C
• Refractive Index: 1.5295
• Storage Temp.: Inert atmosphere,Room Temperature
• BRN: 2207649
• CAS DataBase Reference: 1-BROMO-6-PHENYLHEXANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-6-PHENYLHEXANE(27976-27-8)
• EPA Substance Registry System: 1-BROMO-6-PHENYLHEXANE(27976-27-8)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• Hazardous Substances Data: 27976-27-8(Hazardous Substances Data)

Usage

General Description

1-Bromo-6-phenylhexane is a chemical compound with the molecular formula C12H17Br. It is an organobromine compound that is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. This chemical is primarily used in the research and development of new drugs and compounds, as it can serve as a building block in the creation of more complex molecules. 1-Bromo-6-phenylhexane is a halogenated organic compound that is known for its ability to undergo various chemical reactions, making it a versatile tool in organic synthesis. It is important to handle this chemical with caution, as it is considered hazardous and should only be used by trained professionals in a controlled laboratory setting.

InChI:InChI=1/C12H17Br/c13-11-7-2-1-4-8-12-9-5-3-6-10-12/h3,5-6,9-10H,1-2,4,7-8,11H2

Synthetic route

6-phenyl-1-hexanol (2430-16-2) → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
With carbon tetrabromide; triphenylphosphine In dichloromethane for 1h;	77%
With phosphorus tribromide In diethyl ether at 0 - 20℃; for 15h;	34%
With phosphorus; sulfuric acid; hydrogen bromide

1 ,6-dibromohexane (629-03-8) + phenyllithium (591-51-5) → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
In tetrahydrofuran; diethyl ether; hexane at -14 - 20℃; for 7h; Inert atmosphere;	70%
In tetrahydrofuran
In tetrahydrofuran; diethyl ether at -10℃; for 0.5h;

phenylmagnesium bromide + 6-bromohexyl 4-methylbenzenesulfonate → 1,6-diphenylhexane (1087-49-6) + (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
With buta-1,3-diene; palladium(II) acetylacetonate In tetrahydrofuran at 20℃; for 3h;	A 8% B 69%
With buta-1,3-diene; nickel dichloride In tetrahydrofuran at 20℃; for 3h;	A 20% B 27%

1 ,6-dibromohexane (629-03-8) + phenylmagnesium bromide → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
With 1,8-diazabicyclo[2.2.2.]octane; (1,2,3,4,5-pentamethyl-cyclopenta-2,4-dienylmethyl)PPh2*BH3; nickel dichloride In tetrahydrofuran; diethyl ether; toluene at 25℃; for 3h;	68%

1 ,6-dibromohexane (629-03-8) + benzene (71-43-2) → (5-bromo-1-methylpentyl)benzene (28591-23-3) + 1,2,3,4-tetrahydro-1,4-dimethylnaphthalene (4175-54-6) + (6-bromohexyl)benzene (27976-27-8) + 1-ethyltetralin (13556-58-6)

Conditions	Yield
With silver trifluoromethanesulfonate for 20h; Heating; Further byproducts given;	A 21% B 24% C 6% D 25%

5-hexen-2-ylbenzene (30134-52-2) → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
With hydrogen bromide; dihydrogen peroxide

6-phenylhexyl acetate (296282-60-5) → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
With hydrogen bromide Heating; Yield given;
With hydrogen bromide Reflux;

6-phenyl-1-hexene (1588-44-9) + hydrogen bromide (10035-10-6, 12258-64-9) + peroxide/s → (6-bromohexyl)benzene (27976-27-8)

(E/Z)-6-Phenylhex-5-enoic acid (16424-56-9, 81077-22-7, 5771-67-5) → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
Multi-step reaction with 4 steps 1: diethyl ether; methanol 2: DIBAL-H / CH2Cl2 / 0.5 h / 0 °C 3: H2 / PtO2 / methanol / 2585.7 Torr 4: NBS, Ph3P / CH2Cl2 / 0.42 h / 0 - 20 °C View Scheme

(4-carboxybutyl)triphenylphosphonium bromide (17814-85-6) → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
Multi-step reaction with 5 steps 1: 1.) NaCH2SOCH3 / 1.) DMSO, RT, 30 min, 2.) DMSO, RT, 1 h 2: diethyl ether; methanol 3: DIBAL-H / CH2Cl2 / 0.5 h / 0 °C 4: H2 / PtO2 / methanol / 2585.7 Torr 5: NBS, Ph3P / CH2Cl2 / 0.42 h / 0 - 20 °C View Scheme

6-phenylhex-5-en-1-ol (98078-15-0) → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: H2 / PtO2 / methanol / 2585.7 Torr 2: NBS, Ph3P / CH2Cl2 / 0.42 h / 0 - 20 °C View Scheme

benzaldehyde (100-52-7) + C-phenyl-C-<2-methoxy-naphthyl-(1)>-methylamine → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
Multi-step reaction with 5 steps 1: 1.) NaCH2SOCH3 / 1.) DMSO, RT, 30 min, 2.) DMSO, RT, 1 h 2: diethyl ether; methanol 3: DIBAL-H / CH2Cl2 / 0.5 h / 0 °C 4: H2 / PtO2 / methanol / 2585.7 Torr 5: NBS, Ph3P / CH2Cl2 / 0.42 h / 0 - 20 °C View Scheme

(E)-6-phenyl-5-hexenoic acid methyl ester (85396-64-1) → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
Multi-step reaction with 3 steps 1: DIBAL-H / CH2Cl2 / 0.5 h / 0 °C 2: H2 / PtO2 / methanol / 2585.7 Torr 3: NBS, Ph3P / CH2Cl2 / 0.42 h / 0 - 20 °C View Scheme

6-phenyl-hexanoic acid methyl ester (5581-76-0) → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: LiBH4 2: sulfuric acid; red phosphorus; aqueous hydrobromic acid View Scheme

2,3-dichlorotetrahydro-2H-pyran (5631-95-8) + aqueous alkaline solution → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
Multi-step reaction with 3 steps 1: (i) Mg, Et2O, (ii) Na 2: H2 / Raney-Ni 3: aq. HBr, H2SO4 View Scheme
Multi-step reaction with 2 steps 2: aq. HBr View Scheme

trans-6-phenyl-4-hexen-1-ol (136054-69-8) → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: H2 / Raney-Ni 2: aq. HBr, H2SO4 View Scheme

benzyl chloride (100-44-7) + sodium compound of α-naphthol → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
Multi-step reaction with 3 steps 1: (i) Mg, Et2O, (ii) Na 2: H2 / Raney-Ni 3: aq. HBr, H2SO4 View Scheme

benzylmagnesium chloride (6921-34-2) + d(-)-mandelic acidamide → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
Multi-step reaction with 2 steps 2: aq. HBr View Scheme

carbon tetrabromide (558-13-4) + hexan-1-ol (111-27-3) → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
With triphenylphosphine In dichloromethane
With triphenylphosphine In dichloromethane
With triphenylphosphine In dichloromethane

(E)-(6-bromohex-3-en1-yl)benzene → (6-bromohexyl)benzene (27976-27-8)

6-bromohexanoyl chloride (22809-37-6) → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
With triethylsilane; aluminium chloride In hexane; dichloromethane; water; benzene

1-phenyl-2-bromoethane (103-63-9) → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: iodine; magnesium / tetrahydrofuran / Inert atmosphere; Reflux 1.2: 1 h / 5 - 10 °C / Inert atmosphere 2.1: hydrogen bromide / Reflux View Scheme

1 ,6-dibromohexane (629-03-8) + bromobenzene (108-86-1) → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
With n-butyllithium In diethyl ether; hexane at 0℃; for 2h; Inert atmosphere;

1 ,6-dibromohexane (629-03-8) + phenylmagnesium bromide (100-58-3) → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
With Cl2CuI(2-)*2Li(1+) In tetrahydrofuran at 20℃; for 2h;

benzyl boronic acid (4463-42-7) + 5-bromopentyl trifluoromethanesulfonate (103935-50-8) → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
With potassium phosphate In toluene at 60℃; for 12h;	13 mg

5-bromopentan-1-ol (34626-51-2) → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: 2,6-dimethylpyridine / dichloromethane / 0.33 h / -78 °C / Inert atmosphere 2: potassium phosphate / toluene / 12 h / 60 °C View Scheme

2-Phenylethyl cyclopropyl carbinol (662143-14-8) → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: lithium bromide; phosphorus tribromide; zinc dibromide View Scheme

6-bromohexanoyl chloride (22809-37-6) + benzene (71-43-2) → (6-bromohexyl)benzene (27976-27-8)

Conditions	Yield
With triethylsilane; aluminium chloride In hexane; dichloromethane; water; benzene

(6-bromohexyl)benzene (27976-27-8) → 6-phenyl-1-hexyl iodide (52121-98-9)

Conditions	Yield
In acetone	99%
With sodium iodide In acetone	99%

(6-bromohexyl)benzene (27976-27-8) → sodium 6-phenylhexane-1-sulfonate

Conditions	Yield
With sodium sulfite In ethanol; water for 24h; Heating;	96%
With sodium sulfite In tetrahydrofuran; ethanol; water at 160℃; for 0.25h; Microwave irradiation;

(6-bromohexyl)benzene (27976-27-8) → 6-phenylhexane-1-thiol (192182-85-7)

Conditions	Yield
Stage #1: (6-bromohexyl)benzene With hexamethyldisilathiane; tetrabutyl ammonium fluoride In tetrahydrofuran at -20 - 20℃; for 12h; Darkness; Stage #2: With ammonium chloride In dichloromethane; water	91%
Multi-step reaction with 2 steps 1: 0.48 g / NaOH View Scheme
With ammonia; thiourea In ethanol; dichloromethane

(6-bromohexyl)benzene (27976-27-8) + 2-(pyrimidin-5-yl)phenol → 5-(2-((6-phenylhexyl)oxy)phenyl)pyrimidine

Conditions	Yield
With potassium carbonate In acetone at 70℃; for 24h; Inert atmosphere; Sealed tube;	85%

(6-bromohexyl)benzene (27976-27-8) + 1,4-dideoxy-2,3:5,6-di-O-isopropylidene-1,4-imino-D-mannitol → N-(phenylhexyl)-1,4-dideoxy-2,3:5,6-di-O-isopropylidene-1,4-imino-D-mannitol

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 10h; Heating;	81%

(6-bromohexyl)benzene (27976-27-8) → hexylbenzene (1077-16-3)

Conditions	Yield
With n-butyllithium; samarium diiodide; dipyrrolidinomethylaminophosphoric acid triamide; tert-butyl alcohol In tetrahydrofuran; hexane at -66 - 21℃;	80%

4-[2-(4-benzyloxyphenyl)-5-methyl-1H-pyrrol-1-yl]phenol (376642-19-2) + (6-bromohexyl)benzene (27976-27-8) → 2-(4-Benzyloxyphenyl)-5-methyl-1-[4-(6-phenylhexyloxy)-phenyl]-1H-pyrrole (376642-36-3)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	79.4%

(6-bromohexyl)benzene (27976-27-8) + C16H16N4O*2ClH → C28H32N4O (1426156-40-2)

Conditions	Yield
With triethylamine In acetonitrile for 15h; Reflux;	77%

4-phenyl-4-cyanopiperidine (40481-13-8) + (6-bromohexyl)benzene (27976-27-8) → 4-Cyano-1-(6-phenylhexyl)-4-phenylpiperidin

Conditions	Yield
	75%

(6-bromohexyl)benzene (27976-27-8) + 4-Piperazin-1-yl-pyrrolo[1,2-a]quinoxaline (195711-50-3) → 4-(4-(6-phenylhexyl)piperazin-1-yl)pyrrolo[1,2-a]quinoxaline

Conditions	Yield
With triethylamine In acetonitrile Reflux;	75%

4-bromo-phenol (106-41-2) + (6-bromohexyl)benzene (27976-27-8) → 6-(p-bromophenoxy)-1-phenylhexane

Conditions	Yield
With sodium hydroxide In dimethyl sulfoxide at 100℃; for 5h; Etherification;	72%

7-hydroxy-8-nitrochromone (101870-11-5) + (6-bromohexyl)benzene (27976-27-8) → 8-nitro-7-<(6-phenylhexyl)oxy>chromone (166529-53-9)

Conditions	Yield
With potassium carbonate; lithium iodide In N,N-dimethyl-formamide at 90℃; for 24h;	68%

4-{2-[2-(4-benzyloxyphenyl)-5-methyl-1H-pyrrol-1-yl]ethyl}phenol (376641-68-8) + (6-bromohexyl)benzene (27976-27-8) → 2-(4-benzyloxyphenyl)-5-methyl-1-{2-[4-(6-phenylhexyloxy)phenyl]ethyl}-1H-pyrrole (376642-23-8)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	67.1%

phenyl sulfamate (19792-91-7) + (6-bromohexyl)benzene (27976-27-8) → phenyl (6-bromo-1-phenylhexyl)sulfamate

Conditions	Yield
Stage #1: phenyl sulfamate; (6-bromohexyl)benzene With aluminum oxide; tert-butyl isocyanide; bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} for 0.166667h; Stage #2: With (PhI(OtBu)2) for 6h; Sealed tube;	65%

Dichloromethyl methyl ether (4885-02-3) + (6-bromohexyl)benzene (27976-27-8) → 4-(6-Bromo-hexyl)-benzaldehyde

Conditions	Yield
With titanium tetrachloride In dichloromethane at 35℃; for 1h; Cooling with ice;	60%
With titanium tetrachloride In dichloromethane at 0 - 35℃; for 0.666667h;

methyl 5-(furan-2-yl)-1,3,4-oxadiazole-2-carboxylate (35403-85-1) + (6-bromohexyl)benzene (27976-27-8) → 7-phenyl-1-(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)-heptan-1-one

Conditions	Yield
Stage #1: (6-bromohexyl)benzene With magnesium In tetrahydrofuran; ethylene dibromide at 23℃; Grignard reaction; Inert atmosphere; Sonication; Stage #2: methyl 5-(furan-2-yl)-1,3,4-oxadiazole-2-carboxylate In tetrahydrofuran; ethylene dibromide at -40℃; for 2h;	57%

methyl 5-(thiophen-2-yl)-1,3,4-oxadiazole-2-carboxylate (35403-82-8) + (6-bromohexyl)benzene (27976-27-8) → 7-phenyl-1-(5-(thien-2-yl)-1,3,4-oxadiazol-2-yl)-heptan-1-one (1042151-27-8)

Conditions	Yield
Stage #1: (6-bromohexyl)benzene With magnesium In tetrahydrofuran; ethylene dibromide at 23℃; Grignard reaction; Inert atmosphere; Sonication; Stage #2: methyl 5-(thiophen-2-yl)-1,3,4-oxadiazole-2-carboxylate In tetrahydrofuran; ethylene dibromide at -40℃; for 2h;	57%

(+/-)-5-benzyl-5-ethyl-4-oxo-1,2-oxathiolane-2,2-dioxide (1097642-11-9) + (6-bromohexyl)benzene (27976-27-8) → (+/-)-5-benzyl-5-ethyl-4-(6'-phenylhexyloxy)-5H-1,2-oxathiole-2,2-dioxide (1127304-80-6)

Conditions	Yield
With tetra-(n-butyl)ammonium iodide; potassium carbonate In acetonitrile at 40℃; for 4h;	56%

methyl 3-(6-bromopyridin-2-yl)-1,2,4-oxadiazole-5-carboxylate (1042151-20-1) + (6-bromohexyl)benzene (27976-27-8) → 1-(3-(6-bromopyridin-2-yl)-1,2,4-oxadiazol-5-yl)-7-phenylheptan-1-one (1042151-37-0)

Conditions	Yield
Stage #1: (6-bromohexyl)benzene With magnesium In tetrahydrofuran; ethylene dibromide at 23℃; Grignard reaction; Inert atmosphere; Sonication; Stage #2: methyl 3-(6-bromopyridin-2-yl)-1,2,4-oxadiazole-5-carboxylate In tetrahydrofuran; ethylene dibromide at -40℃; for 2h;	55%

(6-bromohexyl)benzene (27976-27-8) + dimethyl amine (124-40-3) → N,N-dimethyl-6-phenylhexylamine (106291-63-8)

Conditions	Yield
In tetrahydrofuran; diethyl ether for 50h; Ambient temperature;	51%

(6-bromohexyl)benzene (27976-27-8) + methyl 5-(pyridin-2-yl)-1,3,4-oxadiazole-2-carboxylate (849798-86-3) → 7-phenyl-1-(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)-heptan-1-one

Conditions	Yield
Stage #1: (6-bromohexyl)benzene With magnesium In tetrahydrofuran; ethylene dibromide at 23℃; Grignard reaction; Inert atmosphere; Sonication; Stage #2: methyl 5-(pyridin-2-yl)-1,3,4-oxadiazole-2-carboxylate In tetrahydrofuran; ethylene dibromide at -40℃; for 2h;	51%
Stage #1: (6-bromohexyl)benzene With magnesium; ethylene dibromide In tetrahydrofuran at 23℃; Inert atmosphere of Ar; Heating; Sonication; Stage #2: methyl 5-(pyridin-2-yl)-1,3,4-oxadiazole-2-carboxylate In tetrahydrofuran at -40℃; for 2h;	51%
Stage #1: (6-bromohexyl)benzene With iodine; magnesium In tetrahydrofuran at 60℃; for 2h; Stage #2: methyl 5-(pyridin-2-yl)-1,3,4-oxadiazole-2-carboxylate In tetrahydrofuran at -40℃; for 4h;	51%

(6-bromohexyl)benzene (27976-27-8) + p-aminoethylbenzoate (94-09-7) → ethyl 4-(6-phenylhexylamino)benzoate (61440-49-1)

Conditions	Yield
In N,N,N,N,N,N-hexamethylphosphoric triamide at 125℃; for 24h;	50%

(6-bromohexyl)benzene (27976-27-8) + trioctylaluminum (1070-00-4) → tetradecylbenzene (1459-10-5)

Conditions	Yield
With potassium fluoride; benzylnixantphos; iron(II) acetate In tetrahydrofuran at 0 - 40℃; for 12h; Negishi Coupling; Inert atmosphere;	50%

(6-bromohexyl)benzene (27976-27-8) + triphenylphosphine (603-35-0) → triphenyl(6-phenylhexyl)phosphonium iodide

Conditions	Yield
With potassium iodide In acetonitrile at 85℃;	43%

(6-bromohexyl)benzene (27976-27-8) + 5-methyl-4-mercaptomethylimidazole hydrochloride (70826-45-8) → 5-Methyl-4-(6-phenyl-hexylsulfanylmethyl)-1H-imidazole (131028-48-3)

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride In water; isopropyl alcohol at 80℃; for 4h;	41%

dibenzyl methylphosphonate (19236-58-9) + (6-bromohexyl)benzene (27976-27-8) → dibenzyl 6-phenylhexylphosphonate (790699-80-8)

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃;	38.5%

Upstream product

• 2430-16-2 6-phenyl-1-hexanol 
• 30134-52-2 5-hexen-2-ylbenzene 
• 629-03-8 1 ,6-dibromohexane 
• 591-51-5 phenyllithium 
• 296282-60-5 6-phenylhexyl acetate 
• 71-43-2 benzene 
• 1588-44-9 6-phenyl-1-hexene 
• 10035-10-6 hydrogen bromide 
• 16424-56-9 (E/Z)-6-Phenylhex-5-enoic acid 
• 17814-85-6 (4-carboxybutyl)triphenylphosphonium bromide 
• 98078-15-0 6-phenylhex-5-en-1-ol 
• 100-52-7 benzaldehyde 
• 85396-64-1 (E)-6-phenyl-5-hexenoic acid methyl ester 
• 5581-76-0 6-phenyl-hexanoic acid methyl ester 

Downstream Products

• 101427-73-0 1-(6-phenyl-hexyl)-piperazine 
• 62607-66-3 6-phenyl-hexane-1-sulfonic acid 
• 26547-51-3 8-phenyloctanoic acid 
• 27976-22-3 Thiosulfuric acid S-[2-(6-phenyl-hexylamino)-ethyl] ester 
• 131028-48-3 5-Methyl-4-(6-phenyl-hexylsulfanylmethyl)-1H-imidazole 
• 120379-26-2 2-(6-Phenylhexyloxy)benzaldehyde 
• 61440-49-1 ethyl 4-(6-phenylhexylamino)benzoate 
• 166529-53-9 8-nitro-7-<(6-phenylhexyl)oxy>chromone 
• 294201-61-9 S-acetyl 6-phenylhexanethiol 
• 1025820-14-7 6-(4-nitrophenyl)hexyl bromide 
• 1025977-82-5 6-(2-nitrophenyl)hexyl bromide 
• 106291-63-8 N,N-dimethyl-6-phenylhexylamine 
• 790699-80-8 dibenzyl 6-phenylhexylphosphonate 
• 192182-85-7 6-phenylhexane-1-thiol 

Relevant articles and documents

Synthetic method of 3-(6-phenylhexyl) phenylboronic acid and derivatives thereof

The invention discloses a synthetic method of 3-(6-phenylhexyl) phenylboronic acid and derivatives thereof, and relates to the technical field of chemical synthesis. The synthesis method of 3-(6-phenylhexyl) phenylboronic acid and derivatives thereof comprises the following synthesis steps: S1, synthesizing an intermediate H from a reactant B and a reactant D by utilizing a low-temperature synthesis step; S2, synthesizing an intermediate I from the reactant F and the intermediate H by utilizing a low-temperature synthesis step; and S3, synthesizing a finished product from a reactant G and the intermediate I by utilizing a low-temperature synthesis step. The invention provides the novel synthesis method of 3-(6-phenylhexyl) phenylboronic acid and derivatives thereof, the reaction steps are shortened to three steps, the materials are simple, the raw materials can be recycled, the reaction yield is improved, and the method has a series of advantages of short reaction time, simplicity in operation, capability of amplifying continuous production, reduction of the reaction cost and the like.

Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides

The need for novel therapeutic options to fight herpesvirus infections still persists. Herein we report the design, synthesis and antiviral evaluation of a new family of non-nucleoside antivirals, derived from 1-[ω-(4-bromophenoxy)alkyl]uracil derivatives - previously reported inhibitors of human cytomegalovirus (HCMV). Introduction of the N-(4-phenoxyphenyl)acetamide side chain at N3 increased their potency and widened activity spectrum. The most active compounds in the series exhibit submicromolar activity against different viral strains of HCMV and varicella zoster virus (VZV) replication in HEL cell cultures. Inactivity against other DNA and RNA viruses, including herpes simplex virus 1/2, points to a novel mechanism of antiviral action.

RECYCLING OF ORGANOTIN COMPOUNDS

A method for the synthesis of a first organic molecule, said method comprising the steps of: a) Reacting a first reactant with an organotin reactant having at least one optionally substituted organic group having from 5 to 20 carbon atoms selected from alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkylthioalkyl, carboxylates and alkylaminoalkyl groups, thereby forming a mixture of a product and a tin-containing by-product, and b) Removing most of the tin-containing by-product from said mixture in such a way as to provide a purified product comprising less than 1000 ppm of remaining tin-containing by- product, wherein said step of removing most of said tin-containing by-product is either an extraction between a first liquid and a second liquid, said second liquid being more polar than said first liquid and at least partly immiscible therewith or is a reversed phase chromatography.