120427-93-2 Usage
Description
4-Ethenyl-1,3-dihydro-2H-indol-2-one is an organic compound that serves as a decomposition product of Ropinirole N-oxide. It is characterized by its beige solid appearance and is derived from the chemical breakdown of Ropinirole N-oxide, which is a pharmaceutical compound.
Uses
Used in Pharmaceutical Industry:
4-Ethenyl-1,3-dihydro-2H-indol-2-one is used as a decomposition product for Ropinirole N-oxide, which is significant in the pharmaceutical industry. Its role as a decomposition product indicates its potential involvement in the synthesis or modification of other pharmaceutical compounds, contributing to the development of new drugs or the improvement of existing ones.
As a decomposition product, 4-Ethenyl-1,3-dihydro-2H-indol-2-one may also be utilized in research and development for understanding the chemical transformations and reactions that occur during the synthesis or degradation of Ropinirole N-oxide and related compounds. This knowledge can be applied to optimize pharmaceutical processes and enhance the efficacy and safety of medications.
Check Digit Verification of cas no
The CAS Registry Mumber 120427-93-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,4,2 and 7 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 120427-93:
(8*1)+(7*2)+(6*0)+(5*4)+(4*2)+(3*7)+(2*9)+(1*3)=92
92 % 10 = 2
So 120427-93-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H9NO/c1-2-7-4-3-5-9-8(7)6-10(12)11-9/h2-5H,1,6H2,(H,11,12)
120427-93-2Relevant articles and documents
A convenient synthesis of 4-(2-hydroxyethyl)indolin-2-one, a useful intermediate for the preparation of both dopamine receptor agonists and protein kinase inhibitors
Matera, Carlo,Quadri, Marta,Pelucchi, Silvia,De Amici, Marco,Dallanoce, Clelia
, p. 1139 - 1144 (2014/06/24)
This paper describes a practical approach to the preparation of 4-(2-hydroxyethyl)indolin-2-one, a key intermediate in the synthesis of dopaminergic agonists such as ropinirole - a drug used in the treatment of Parkinson's disease and restless legs syndrome - and of two sets of protein kinase inhibitors. The sequence starts from commercially available 2-(2-methyl-3-nitrophenyl)acetic acid, which is converted in five steps into the desired target compound. This procedure offers a convenient alternative route to existing methodologies, given its milder reaction conditions, ease of implementation, and its overall yield (59 %).
Some synthetic approaches to ropinirole (SK and F 101468-A): A potent dopamine receptor agonist
Hayler,Howie,Giles,Negus,Oxley,Walsgrove,Walsh,Dagger,Fortunak,Mastrocola
, p. 875 - 882 (2007/10/02)
Three new routes to ropinirole (SK and F 101468-A, 1) are described each involving the preparation of 3-chlorooxindole intermediates of type 3 from β-nitrostyrenes as the pivotal step. The superiority of sulphonate esters 17a-c as direct precursors to 1 over the bromide 11 is also described.