168476-58-2

Basic information

• Product Name: Benzeneethanol, 2-(chloroMethyl)-, 1-benzoate
• Synonyms: Benzeneethanol, 2-(chloroMethyl)-, 1-benzoate
• CAS NO: 168476-58-2
• Molecular Formula: C₁₆H₁₅ClO₂
• Molecular Weight: 291.74944
• Mol File: 168476-58-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzeneethanol, 2-(chloroMethyl)-, 1-benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneethanol, 2-(chloroMethyl)-, 1-benzoate(168476-58-2)
• EPA Substance Registry System: Benzeneethanol, 2-(chloroMethyl)-, 1-benzoate(168476-58-2)

Safety Data

• Hazardous Substances Data: 168476-58-2(Hazardous Substances Data)

Upstream product

• 493-05-0 isochromane 
• 98-88-4 benzoyl chloride 
• 60-12-8 2-phenylethanol 

Downstream Products

• 139122-15-9 benzoic acid (2-formyl)phenethyl ester 
• 91374-21-9 Ropinirole 
• 120427-93-2 4-ethylenyl-1,3-dihydro-2H-indol-2-one 
• 139122-19-3 4-(2'-hydroxyethyl)-1,3-dihydro-2H-indol-2-one 
• 139122-18-2 4-(2-benzoyloxyethyl)-1,3-dihydro-2H-indolin-2-one 
• 139122-17-1 4-[2-(benzoyloxy)ethyl]-3-chloro-1,3-dihydro-2H-indolin-2-one 
• 139122-22-8 2-(2'-oxo-2,3-dihydro-4-indolyl)ethyl benzenesulphonate 
• 139122-20-6 2-(2-oxo-2,3-dihydro-1H-indol-4-yl)ethyl-4-methylbenzene-1-sulfonate 
• 139122-16-0 benzoic acid (2-(2-nitroethenyl))phenethyl ester 
• 120427-96-5 4-(2'-bromoethyl)-1,3-dihydro-2H-indol-2-one 
• 91374-20-8 ropinirole hydrochloride 

Relevant articles and documents

Design, synthesis, and biological evaluation of structurally constrained hybrid analogues containing ropinirole moiety as a novel class of potent and selective dopamine D3 receptor ligands

Two series of hybrid analogues were designed, synthesized, and evaluated as a novel class of selective ligands for the dopamine D3 receptor. Binding affinities of target compounds were determined (using the method of radioligand binding assay). Compared to comparator agent BP897, compounds 2a and 2c were found to demonstrate a considerable binding affinity and selectivity for D3 receptor, and especially compound 2h was similarly potent and more selective D3R ligand than BP897, a positive reference. Thus, they may provide valuable information for the discovery and development of highly potent dopamine D3 receptor ligands with outstanding selectivity.

Improved preparation method for ropinirole hydrochloride

The invention discloses an improved preparation method for ropinirole hydrochloride. The ropinirole hydrochloride is a compound shown in the formula I and is prepared through a series of reactions with 2-phenylethanol as a starting raw material. Compared with the prior art, according to the method, raw materials are cheap and easy to get, reaction conditions are mild, technological operation is easy, control is easy, the product is high in total yield and purity, and the method is suitable for industrial production.

Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors

The present invention is directed to a class indolinone compounds, hexahydro-cyclohepta-pyrrole oxindoles, which are useful as protein kinase inhibitors.