1204357-83-4

Basic information

• Product Name: 1-(4-fluorophenyl)-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 1-(4-fluorophenyl)-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 1204357-83-4
• Molecular Weight: 317.36
• Mol File: 1204357-83-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-fluorophenyl)-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline(1204357-83-4)
• EPA Substance Registry System: 1-(4-fluorophenyl)-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline(1204357-83-4)

Safety Data

• Hazardous Substances Data: 1204357-83-4(Hazardous Substances Data)

Upstream product

• 832-92-8 mescaline hydrochloride 
• 6316-70-7 3,4,5-trimethoxy-β-nitrostyrene 
• 1204357-65-2 1-(4-fluorophenyl)-6,7,8-trimethoxy-3,4-dihydroisoquinoline 
• 1204357-85-6 C₁₈H₂₀FNO₄ 

Relevant articles and documents

Synthesis and biological evaluation of 1-phenyl-1,2,3,4-dihydroisoquinoline compounds as tubulin polymerization inhibitors

A series of 1-phenyl-3,4-dihydroisoquinoline derivatives and several 1-phenyl-1,2,3,4-tetrahydroisoquinoline, 1-phenyl-isoquinoline analogues were synthesized, and their cytotoxicity and tubulin polymerization inhibitory activity were evaluated. The 1-phenyl-3,4-dihydroisoquinoline compounds were found to be potential tubulin polymerization inhibitors. Compound 5n, bearing a 3′-OH and 4′-OCH3 substituted 1-phenyl B-ring, was shown to confer optimal bioactivity. The single-crystal structure of 5n was further determined by X-ray diffraction, and the binding mode of 5n to tubulin was obtained by molecular docking, which can explain the structure-activity relationships. The studies presented here provide a new structural type for the development of novel antitumor agents.