120443-18-7

Basic information

• Product Name: (S)-3-(((3-(2-(7-chloroquinolin-2-yl)-(E)-ethenyl)phenyl)((3-(dimethylamino)-3-oxopropyl)thio)methyl)thio)propionic acid methyl ester
• Synonyms: (S)-3-(((3-(2-(7-chloroquinolin-2-yl)-(E)-ethenyl)phenyl)((3-(dimethylamino)-3-oxopropyl)thio)methyl)thio)propionic acid methyl ester
• CAS NO: 120443-18-7
• Molecular Weight: 529.124
• Mol File: 120443-18-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (S)-3-(((3-(2-(7-chloroquinolin-2-yl)-(E)-ethenyl)phenyl)((3-(dimethylamino)-3-oxopropyl)thio)methyl)thio)propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(((3-(2-(7-chloroquinolin-2-yl)-(E)-ethenyl)phenyl)((3-(dimethylamino)-3-oxopropyl)thio)methyl)thio)propionic acid methyl ester(120443-18-7)
• EPA Substance Registry System: (S)-3-(((3-(2-(7-chloroquinolin-2-yl)-(E)-ethenyl)phenyl)((3-(dimethylamino)-3-oxopropyl)thio)methyl)thio)propionic acid methyl ester(120443-18-7)

Safety Data

• Hazardous Substances Data: 120443-18-7(Hazardous Substances Data)

Upstream product

• 626-19-7 Isophthalaldehyde 
• 115104-48-8 (R)-Methoxy-phenyl-thioacetic acid S-[[3-(tert-butyl-diphenyl-silanyloxymethyl)-phenyl]-(2-dimethylcarbamoyl-ethylsulfanyl)-methyl] ester 
• 115104-47-7 3-[[3-(tert-Butyl-diphenyl-silanyloxymethyl)-phenyl]-(2-dimethylcarbamoyl-ethylsulfanyl)-methylsulfanyl]-propionic acid methyl ester 
• 115104-50-2 3-[(2-Dimethylcarbamoyl-ethylsulfanyl)-(3-hydroxymethyl-phenyl)-methylsulfanyl]-propionic acid methyl ester 
• 110130-71-7 3-(((tert-butyldiphenylsilyl)oxy)methyl)benzaldehyde 
• 115104-25-1 2-(Bromomethyl)-7-chloroquinoline 
• 52010-98-7 3-(hydroxymethyl)benzaldehyde 
• 4965-33-7 2-methyl-7-chloroquinoline 
• 115125-09-2 ((7-chloroquinolin-2-yl)methyl)triphenylphosphonium bromide 
• 115104-51-3 3-[(2-Dimethylcarbamoyl-ethylsulfanyl)-(3-formyl-phenyl)-methylsulfanyl]-propionic acid methyl ester 
• 115104-48-8 (R)-Methoxy-phenyl-thioacetic acid S-[[3-(tert-butyl-diphenyl-silanyloxymethyl)-phenyl]-(2-dimethylcarbamoyl-ethylsulfanyl)-methyl] ester 
• 115104-47-7 3-[[3-(tert-Butyl-diphenyl-silanyloxymethyl)-phenyl]-(2-dimethylcarbamoyl-ethylsulfanyl)-methylsulfanyl]-propionic acid methyl ester 
• 115104-50-2 3-[(2-Dimethylcarbamoyl-ethylsulfanyl)-(3-hydroxymethyl-phenyl)-methylsulfanyl]-propionic acid methyl ester 
• 115104-51-3 3-[(2-Dimethylcarbamoyl-ethylsulfanyl)-(3-formyl-phenyl)-methylsulfanyl]-propionic acid methyl ester 

Downstream Products

• 120443-17-6 (+)-MK-571 
• 115104-28-4 (-)-L-660,711 
• 115104-28-4 (+)-L-660,711 

Relevant articles and documents

A Practical Chemoenzymatic Synthesis Of An LTD4 Antagonist

Enzymatic asymmetrization of a prochiral diester having 4 bonds between the ester group and prochiral center is the comerstone of a short and efficient synthesis of an LTD4 antagonist.The enzymatic hydrolysis occurs in a heterogeneous slurry, but a kineti

Stereospecific synthesis, assignment of absolute configuration, and biological activity of the enantiomers of 3-[[[3-[2-(7-chloroquinolin-2-yl)-(E)-ethenyl]phenyl][[3-(dimethylami no)-3-oxopropyl]thio]methyl]thio]propionic acid, a potent and specific leuk

The enantiomers of the leukotriene D4 antagonist 3-[[[3-[2-(7-chloroquin-2-yl)-(E)-ethenyl]phenyl][[3-(dimethylamino)- 3-oxopropyl]thio]methyl]thio]propionic acid (L-660,711)(MK-571) have been prepared, their absolute stereochemistry has been a

ASYMMETRIC DITHIOACETALS III: THE PREPARATION OF THE ENANTIOMERS OF 3-((((3-(2-(7-CHLOROQUINOLIN-2-YL)-(E)-ETHENYL)PHENYL)-3-DIMETHYLAMINO-3-OXOPROPYLTHIO)METHYL)THIO)PROPIONIC ACID (L-660,711) (MK-571), AN ANTAGONIST OF LEUKOTRIENE D4

The application of a novel method for the preparation of chiral dithioacetals to the synthesis of the enantiomers of L-660,711, an antagonist of leukotriene D4, is described.Reaction of 3-(t-butyldiphenylsilyloxymethyl)benzaldehyde or isophthal