120759-94-6Relevant articles and documents
Magnesium Chloride-Promoted Michael Addition of Dimethylsilyl Enolates to α-Enones
Miura, Katsukiyo,Nakagawa, Takahiro,Hosomi, Akira
, p. 2068 - 2070 (2007/10/03)
In the presence of MgCl2, dimethylsilyl (DMS) enolates 1 smoothly reacted with α-enones in DMF to form 1,5-diketones 3 in moderate to high yields. The Michael addition proceeded with moderate to high anti-diastereoselectivity.
A New Annulation Reagent, 2-Oxo-3-alkenylphosphonates. Reactions with Carbonyl-Stabilized Carboanions or Silyl Enol Ethers Leading to Cyclohexanones
Wada, Eiji,Funakoshi, Junji,Kanemasa, Shuji
, p. 2456 - 2464 (2007/10/02)
The reactions of 2-oxo-3-alkenylphosphonates with carbonyl-stabilized carbanions directly lead to 2-cyclohexen-1-ones through a sequence of Michael reaction and intramolecular Horner-Emmons olefination.On the other hand, the Lewis acid-mediated reactions with silyl enol ethers produce 1,5-diketones as Michael adducts, which then undergo cyclization on treatment with sodium hydride or triethylamine/zinc (II) bromide to afford 2-cyclohexen-1-ones or 2-phosphinyl-2-cyclohexen-1-ones, respectively.