120944-75-4 Usage
Description
BOC-PEN(MOB)-OH, also known as Boc-S-4-methoxybenzyl-L-penicillamine, is an amino acid building block derived from L-penicillamine and is utilized in the synthesis of peptides. It is characterized by its white powder form and plays a significant role in the rapidly expanding peptide drug market, where the fast and reliable synthesis of peptides is of great importance.
Uses
Used in Pharmaceutical Industry:
BOC-PEN(MOB)-OH is used as an amino acid building block for peptide synthesis, which is crucial in the development of new peptide-based drugs. Its role in the pharmaceutical industry is to facilitate the creation of innovative and effective treatments for various medical conditions.
Used in Research and Development:
In the field of research and development, BOC-PEN(MOB)-OH is employed as a key component in the synthesis of novel peptides. This allows scientists to explore new therapeutic possibilities and develop a deeper understanding of peptide-based drug mechanisms.
Used in Drug Delivery Systems:
BOC-PEN(MOB)-OH can also be utilized in the development of drug delivery systems, where its properties can be harnessed to improve the bioavailability and efficacy of peptide-based drugs. This application can lead to the creation of more targeted and efficient treatments for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 120944-75-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,9,4 and 4 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 120944-75:
(8*1)+(7*2)+(6*0)+(5*9)+(4*4)+(3*4)+(2*7)+(1*5)=114
114 % 10 = 4
So 120944-75-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H27NO5S/c1-17(2,3)24-16(22)19-14(15(20)21)18(4,5)25-11-12-7-9-13(23-6)10-8-12/h7-10,14H,11H2,1-6H3,(H,19,22)(H,20,21)/t14-/m1/s1
120944-75-4Relevant articles and documents
Bio-inspired nitrile hydration by peptidic ligands based on L-cysteine, L-methionine or L-penicillamine and pyridine-2,6-dicarboxylic acid
Byrne, Cillian,Houlihan, Kate M.,Devi, Prarthana,Jensen, Paul,Rutledge, Peter J.
, p. 20751 - 20767 (2014)
Nitrile hydratase (NHase, EC 4.2.1.84) is a metalloenzyme which catalyses the conversion of nitriles to amides. The high efficiency and broad substrate range of NHase have led to the successful application of this enzyme as a biocatalyst in the industrial syntheses of acrylamide and nicotinamide and in the bioremediation of nitrile waste. Crystal structures of both cobalt(III)- and iron(III)-dependent NHases reveal an unusual metal binding motif made up from six sequential amino acids and comprising two amide nitrogens from the peptide backbone and three cysteine-derived sulfur ligands, each at a different oxidation state (thiolate, sulfenate and sulfinate). Based on the active site geometry revealed by these crystal structures, we have designed a series of small-molecule ligands which integrate essential features of the NHase metal binding motif into a readily accessible peptide environment. We report the synthesis of ligands based on a pyridine-2,6-dicarboxylic acid scaffold and L-cysteine, L- S-methylcysteine, L-methionine or L-penicillamine. These ligands have been combined with cobalt(III) and iron(III) and tested as catalysts for biomimetic nitrile hydration. The highest levels of activity are observed with the L-penicillamine ligand which, in combination with cobalt(III), converts acetonitrile to acetamide at 1.25 turnovers and benzonitrile to benzamide at 1.20 turnovers.
