387868-34-0 Usage
Description
H-BETA,BETA-DIMETHYL-L-CYS(PMEOBZL)-OH, also known as S-4-Methoxybenzyl-L-penicillamine, is a chemical compound with the molecular formula C11H15NO3S. It is a white powder and is primarily used in the synthesis of peptidic-ligands as a catalyst for biomimetic nitrile hydration. H-BETA,BETA-DIMETHYL-L-CYS(PMEOBZL)-OH plays a crucial role in the development of new pharmaceuticals and has potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
H-BETA,BETA-DIMETHYL-L-CYS(PMEOBZL)-OH is used as a catalyst in the synthesis of peptidic-ligands for biomimetic nitrile hydration. Its application in this process is essential for the development of new drugs and pharmaceutical compounds, as it aids in the formation of complex molecular structures that can target specific biological pathways.
Used in Chemical Research:
As a white powder with unique chemical properties, H-BETA,BETA-DIMETHYL-L-CYS(PMEOBZL)-OH is also used in chemical research for studying various reaction mechanisms and exploring new synthetic routes. Its versatility as a catalyst makes it a valuable tool for chemists working on the development of novel compounds and materials.
Used in Catalyst Development:
H-BETA,BETA-DIMETHYL-L-CYS(PMEOBZL)-OH is used as a catalyst in the development of new catalytic systems for various chemical reactions. Its ability to facilitate biomimetic nitrile hydration makes it a promising candidate for the design of more efficient and selective catalysts, which can be applied in various industrial processes.
Check Digit Verification of cas no
The CAS Registry Mumber 387868-34-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,8,7,8,6 and 8 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 387868-34:
(8*3)+(7*8)+(6*7)+(5*8)+(4*6)+(3*8)+(2*3)+(1*4)=220
220 % 10 = 0
So 387868-34-0 is a valid CAS Registry Number.
387868-34-0Relevant articles and documents
Bio-inspired nitrile hydration by peptidic ligands based on L-cysteine, L-methionine or L-penicillamine and pyridine-2,6-dicarboxylic acid
Byrne, Cillian,Houlihan, Kate M.,Devi, Prarthana,Jensen, Paul,Rutledge, Peter J.
, p. 20751 - 20767 (2015/02/19)
Nitrile hydratase (NHase, EC 4.2.1.84) is a metalloenzyme which catalyses the conversion of nitriles to amides. The high efficiency and broad substrate range of NHase have led to the successful application of this enzyme as a biocatalyst in the industrial syntheses of acrylamide and nicotinamide and in the bioremediation of nitrile waste. Crystal structures of both cobalt(III)- and iron(III)-dependent NHases reveal an unusual metal binding motif made up from six sequential amino acids and comprising two amide nitrogens from the peptide backbone and three cysteine-derived sulfur ligands, each at a different oxidation state (thiolate, sulfenate and sulfinate). Based on the active site geometry revealed by these crystal structures, we have designed a series of small-molecule ligands which integrate essential features of the NHase metal binding motif into a readily accessible peptide environment. We report the synthesis of ligands based on a pyridine-2,6-dicarboxylic acid scaffold and L-cysteine, L- S-methylcysteine, L-methionine or L-penicillamine. These ligands have been combined with cobalt(III) and iron(III) and tested as catalysts for biomimetic nitrile hydration. The highest levels of activity are observed with the L-penicillamine ligand which, in combination with cobalt(III), converts acetonitrile to acetamide at 1.25 turnovers and benzonitrile to benzamide at 1.20 turnovers.
