1210056-55-5

Basic information

• Product Name: 2-(3-methylbut-2-enyl)-2-(3-oxobutyl)-1,3-cyclohexanedione
• Synonyms: 2-(3-methylbut-2-enyl)-2-(3-oxobutyl)-1,3-cyclohexanedione
• CAS NO: 1210056-55-5
• Molecular Weight: 250.338
• Mol File: 1210056-55-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(3-methylbut-2-enyl)-2-(3-oxobutyl)-1,3-cyclohexanedione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-methylbut-2-enyl)-2-(3-oxobutyl)-1,3-cyclohexanedione(1210056-55-5)
• EPA Substance Registry System: 2-(3-methylbut-2-enyl)-2-(3-oxobutyl)-1,3-cyclohexanedione(1210056-55-5)

Safety Data

• Hazardous Substances Data: 1210056-55-5(Hazardous Substances Data)

Upstream product

• 56946-66-8 2-(3-methylbut-2-en-1-yl)cyclohexane-1,3-dione 
• 78-94-4 methyl vinyl ketone 

Relevant articles and documents

A practical protocol for asymmetric synthesis of wieland-miescher and hajos-parrish ketones catalyzed by a simple chiral primary amine

This article describes a simple chiral primary amine catalyzed efficient and practical protocol for the large-scale synthesis of Wieland-Miescher and Hajos-Parrish ketones as well as their analogues. Georg Thieme Verlag Stuttgart. New York.

Efficient solvent-free robinson annulation protocols for the highly enantioselective synthesis of the wieland-miescher ketone and analogues

A highly efficient (93% overall yield) and enantioselective (94% ee) synthesis of the WielandMiescher ketone (10-g scale) through a solvent-free Robinson annulation procedure is reported. The process involves only 1 mol% triethylamine as the base in the initial Michael process and the organocatalyst N-tosyl-(Sa)-binam-L-prolinamide (2mol%) and benzoic acid (0.5 mol% ) for the intramolecular aldol process. This green protocol is applied to a wide range of valuable building block analogues of the Wieland-Miescher ketone (10 examples). Among these, a noteworthy compound for terpene synthesis is the 8a-allyl derivative, which is prepared in 93% yield and 97% ee in a process allowing the recovery and reutilization of the organocatalyst. Furthermore, a one-pot, two-step process has also been developed.