121019-61-2Relevant articles and documents
A New Synthesis of 4-Aminooxazoles from α-Oxonitriles
Lakhan, Ram,Singh, Ram Lakhan
, p. 1413 - 1417 (2007/10/02)
A general synthesis is described for the preparation of 4-amino-2,5-disubstituted oxazoles 2.The interaction of α-oxonitriles 1 with equimolecular amounts of aromatic or aliphatic aldehydes, and excess of anhydrous ammonium acetate in glacial acetic acid at 110-120 deg C for 3-6 hours gives 2 in 40-65percent yields.A plausible reaction mechanism for the formation of 2 is also suggested.