14271-83-1

Basic information

• Product Name: (4-METHOXY-PHENYL)-OXO-ACETONITRILE
• Synonyms: (4-METHOXY-PHENYL)-OXO-ACETONITRILE;4-METHOXYBENZOYL CYANIDE
• CAS NO: 14271-83-1
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.16
• Mol File: 14271-83-1.mol
• Article Data: 30

Chemical Properties

• Melting Point: 63-64 °C
• Boiling Point: 271.3±23.0 °C(Predicted)
• Appearance: /
• Density: 1.164±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (4-METHOXY-PHENYL)-OXO-ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-METHOXY-PHENYL)-OXO-ACETONITRILE(14271-83-1)
• EPA Substance Registry System: (4-METHOXY-PHENYL)-OXO-ACETONITRILE(14271-83-1)

Safety Data

• Hazardous Substances Data: 14271-83-1(Hazardous Substances Data)

Usage

General Description

(4-METHOXY-PHENYL)-OXO-ACETONITRILE, also known as 4-methoxyphenacyl cyanide, is a chemical compound with the molecular formula C9H7NO2. It is a white to light yellow solid that is used in the synthesis of pharmaceuticals and other organic compounds. (4-METHOXY-PHENYL)-OXO-ACETONITRILE is commonly used as an intermediate in the production of various medications and organic substances. It is also known to have potential applications in various industries, such as pharmaceuticals, agrochemicals, and dyes. However, it is important to handle this chemical with care, as it can be toxic and harmful if not used properly.

Upstream product

• 33646-40-1 4-methoxymandelonitrile 
• 1823-76-3 p-methoxy-isonitrosoacetophenone 
• 108-24-7 acetic anhydride 
• 74-90-8 hydrogen cyanide 
• 100-07-2 4-methoxy-benzoyl chloride 
• 460-19-5 ethanedinitrile 
• 100-66-3 methoxybenzene 
• 75-36-5 acetyl chloride 
• 544-92-3 copper(I) cyanide 
• 1115-12-4 carbonyl cyanide 
• 201230-82-2 carbon monoxide 
• 696-62-8 para-iodoanisole 
• 151-50-8 potassium cyanide 
• 66985-48-6 2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetonitrile 

Downstream Products

• 7099-91-4 p-methoxybenzoylformic acid 
• 935764-11-7 2-(4-methoxyphenyl)-2-oxoacetamide 
• 40513-43-7 2-amino-1-(4-methoxy-phenyl)-ethanone 
• 55275-61-1 2-amino-1-(4-methoxyphenyl)ethanol 
• 55-81-2 4-Methoxyphenethylamine 
• 28191-29-9 2-(4-methoxyphenyl)-1,1,2-tricyanoethylene 
• 37964-77-5 diphenyl(4-methoxyphenyl)acetonitrile 
• 6578-48-9 N-(α-Cyan-4-methoxy-benzyliden)-N'-diaminomethylen-hydrazin 
• 6965-38-4 N’-hydroxy-2-(4-methoxyphenyl)ethanimidamide 
• 5955-81-7 p-Methoxyphenyl-glyoxylsaeurethioamid 
• 7465-88-5 4-methoxy-N-phenylbenzamide 
• 49615-69-2 3-amino-4-(p-methoxyphenyl)-1,2,5-oxadiazole 
• 121019-61-2 4-amino-5-p-methoxyphenyl-2-nitrophenyloxazole 
• 129803-25-4 α-Cyanobenzyl p-Methoxybenzoate 

Relevant articles and documents

Acyl Cyanides as Bifunctional Reagent: Application in Copper-Catalyzed Cyanoamidation and Cyanoesterification Reaction

Cu-catalyzed domino decyanation and cyanation reaction of acyl cyanides with amines or alcohols have been developed. The cyano sources were generated in situ via C-CN cleavage yielding the corresponding cyano substituted amides or esters in moderate to excellent yields. This approach features a cheap copper catalyst, domino decyanation and cyanation reaction, readily available starting materials, broad substrate scope, operational simplicity, and the potential for further transformation of the cyano group.

Palladium-Catalyzed One-Pot Four-Component Synthesis of β-Cyano-α,β-unsaturated Ketones Using Calcium Carbide as an Acetylene Source and Potassium Hexacyanoferrate(II) as an Eco-Friendly Cyanide Source

Palladium-catalyzed one-pot four-component synthesis of β-cyano-α,β-unsaturated ketones by the reactions of aryl halides, calcium carbide, potassium hexacyanoferrate(II) and aroyl chlorides is described. The salient features of this protocol are the direct use of easy-to-handle acetylene source and eco-friendly cyanide source, wide scope of substrates with good functional group tolerance, and simple work-up procedure. (Figure presented.).

Acceptorless and Base-free Dehydrogenation of Cyanohydrin with (η6-Arene)halide(Bidentate Phosphine)ruthenium(II) Complex

Ruthenium-catalyzed dehydrogenation of cyanohydrins under acceptorless and base-free conditions was demonstrated for the first time in the synthesis of acyl cyanide. As opposed to the thermodynamically preferred elimination of hydrogen cyanide, the dehydrogenation of cyanohydrins could be kinetically controlled with ruthenium (II) bidentate phosphine complexes. The effects of the arene, phosphine ligands and counter anions were investigated in regard to catalytic activity and selectivity. Selective dehydrogenation can occur via β-hydride elimination with the experimentally observed [(alkoxide)Ru] complex. (Figure presented.).