6965-38-4

Basic information

• Product Name: N-HYDROXY-2-(4-METHOXY-PHENYL)-ACETAMIDINE
• Synonyms: Nsc67593;BENZENEETHANIMIDAMIDE,N-HYDROXY-4-METHOXY-
• CAS NO: 6965-38-4
• Molecular Formula: C₉H₁₂N₂O₂
• Molecular Weight: 180.2038
• Mol File: 6965-38-4.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 376.3°Cat760mmHg
• Flash Point: 181.4°C
• Appearance: /
• Density: 1.17g/cm³
• CAS DataBase Reference: N-HYDROXY-2-(4-METHOXY-PHENYL)-ACETAMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-HYDROXY-2-(4-METHOXY-PHENYL)-ACETAMIDINE(6965-38-4)
• EPA Substance Registry System: N-HYDROXY-2-(4-METHOXY-PHENYL)-ACETAMIDINE(6965-38-4)

Safety Data

• Hazardous Substances Data: 6965-38-4(Hazardous Substances Data)

Usage

Description

N-HYDROXY-2-(4-METHOXY-PHENYL)-ACETAMIDINE is a chemical compound with the molecular formula C9H12N2O2. It is a derivative of acetamidine and contains a hydroxyl group and a 4-methoxy-phenyl substituent. N-HYDROXY-2-(4-METHOXY-PHENYL)-ACETAMIDINE has potential pharmaceutical applications, particularly in the field of medicinal chemistry. It may exhibit biological activity and is of interest for its potential use as a drug or as a starting material for the synthesis of other pharmaceutical compounds. Further research and studies are needed to fully understand the properties and potential applications of N-HYDROXY-2-(4-METHOXY-PHENYL)-ACETAMIDINE.

Uses

Used in Pharmaceutical Industry:
N-HYDROXY-2-(4-METHOXY-PHENYL)-ACETAMIDINE is used as a potential drug candidate for various therapeutic applications due to its unique chemical structure and potential biological activity. Its hydroxyl group and 4-methoxy-phenyl substituent may contribute to its pharmacological properties, making it a promising compound for the development of new medications.
Used in Medicinal Chemistry Research:
N-HYDROXY-2-(4-METHOXY-PHENYL)-ACETAMIDINE is used as a starting material for the synthesis of other pharmaceutical compounds. Its chemical structure can be modified to create new derivatives with potentially improved or novel therapeutic effects. N-HYDROXY-2-(4-METHOXY-PHENYL)-ACETAMIDINE serves as a valuable building block for the design and development of innovative drugs in the field of medicinal chemistry.
Further research and studies are required to explore the full potential of N-HYDROXY-2-(4-METHOXY-PHENYL)-ACETAMIDINE in various applications and to optimize its properties for specific uses in the pharmaceutical and medicinal chemistry industries.

Upstream product

• 14271-83-1 4-methoxybenzoyl cyanide 
• 104-47-2 p-methoxybenzylnitrile 
• 22442-48-4 3-(4-methoxyphenyl)propionitrile 
• 7732-18-5 water 
• 584-08-7 potassium carbonate 

Downstream Products

• 102151-88-2 4-carbethoxy-2-<(4-methoxyphenyl)methyl>imidazole 
• 102151-90-6 4-cyano-2-<(4-methoxyphenyl)methyl>imidazole 
• 102151-92-8 4-acetyl-2-<(4-hydroxyphenyl)methyl>imidazole 
• 102151-91-7 4-acetyl-2-<(4-methoxyphenyl)methyl>imidazole 
• 102151-89-3 4-carbamoyl-2-<(4-methoxyphenyl)methyl>imidazole 
• 102152-32-9 (S)-4-acetyl-2-<<4-<3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-2-hydroxypropoxy>phenyl>methyl>imidazole 
• 943003-20-1 {{4-{[3-(4-methoxybenzyl)-1,2,4-oxadiazol-5-yl]methyl}cyclohexyl}}-N,N-dimethyl(phenyl)methanamine 
• 425401-92-9 5-phenyl-3-(4-methoxybenzyl)-1,2,4-oxadiazole 
• 1345020-48-5 (S)-tert-butyl 1-(3-(4-methoxybenzyl)-1,2,4-oxadiazol-5-yl)-3-methylbutylcarbamate 
• 1345020-66-7 (S)-benzyl 2-(3-(4-methoxybenzyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboxylate 

Relevant articles and documents

COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES

The present disclosure relates to compounds according to Formulae disclosed herein, useful for treating diseases.

Nitrobenzofurazan derivatives of N′-hydroxyamidines as potent inhibitors of indoleamine-2,3-dioxygenase 1

Tryptophan metabolism through the kynurenine pathway is considered as a crucial mechanism in immune tolerance. Indoleamine 2,3-dioxygenase 1 (IDO1) plays a key role in tryptophan catabolism in the immune system and it is also considered as an important therapeutic target for the treatment of cancer and other diseases that are linked with kynurenine pathway. In this study, a series of nitrobenzofurazan derivatives of N′-hydroxybenzimidamides (1) and N′-hydroxy-2-phenylacetimidamides (2) were synthesized and their inhibitory activities against human IDO1 enzyme were tested using in-vitro and cellular enzyme activity assay. The optimization leads to the identification of potent compounds, 1d, 2i and 2k (IC50 = 39-80 nM), which are either competitive or uncompetitive inhibitors of IDO1 enzyme. These compounds also showed IDO1 inhibition potencies in the nanomolar range (IC50 = 50-71 nM) in MDA-MB-231 cells with no/negligible amount of cytotoxicity. The stronger selectivity of the potent compounds for IDO1 enzyme over tryptophan 2,3-dioxygenase (TDO) enzyme (312-1593-fold) also makes them very attractive for further immunotherapeutic applications.

Design and synthesis of N-methylpyrimidone derivatives as HIV-1 integrase inhibitors

A series of novel β-diketo derivatives which combined the virtues of dihydroxypyrimidine carboxamide derived from the evolution of DKA and polyhydroxylated aromatics moieties, were designed and synthesized as potential HIV-1 integrase (IN) inhibitors and