7465-88-5

Basic information

• Product Name: N-Phenyl-4-methoxybenzamide
• Synonyms: 4-Methoxy-N-phenylbenzamide;N-Phenyl-4-methoxybenzamide;p-Anisanilide;BenzaMide, 4-Methoxy-N-phenyl-
• CAS NO: 7465-88-5
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.26
• Mol File: 7465-88-5.mol
• Article Data: 208

Chemical Properties

• Boiling Point: 301.5°C at 760 mmHg
• Flash Point: 136.1°C
• Appearance: /
• Density: 1.181g/cm³
• Vapor Pressure: 0.00105mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N-Phenyl-4-methoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Phenyl-4-methoxybenzamide(7465-88-5)
• EPA Substance Registry System: N-Phenyl-4-methoxybenzamide(7465-88-5)

Safety Data

• Hazardous Substances Data: 7465-88-5(Hazardous Substances Data)

Usage

General Description

N-Phenyl-4-methoxybenzamide, also known as 4-methoxy-N-phenylbenzamide, is a chemical compound with the molecular formula C14H13NO2. It is a white crystalline solid that is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. N-Phenyl-4-methoxybenzamide has been reported to possess anti-inflammatory and analgesic properties, making it a potential candidate for the development of new medicines. Additionally, this compound has been studied for its potential use in the treatment of neurodegenerative diseases and cancer. However, further research is needed to fully understand the biological activities and potential therapeutic applications of N-Phenyl-4-methoxybenzamide.

InChI:InChI=1/C14H13NO2/c1-17-13-9-7-11(8-10-13)14(16)15-12-5-3-2-4-6-12/h2-10H,1H3,(H,15,16)

Upstream product

• 79-37-8 oxalyl dichloride 
• 60-29-7 diethyl ether 
• 10147-61-2 (Z)-(4-methoxyphenyl)(phenyl)methanone oxime 
• 10147-60-1 (4-methoxyphenyl)phenylmethanone oxime 
• 59101-33-6 N-benzoyl-O-(4-methoxy-benzoyl)-hydroxylamine 
• 123-11-5 4-methoxy-benzaldehyde 
• 98-95-3 nitrobenzene 
• 62-53-3 aniline 
• 103-71-9 phenyl isocyanate 
• 100-66-3 methoxybenzene 
• 100-09-4 4-methoxybenzoic acid 
• 100-07-2 4-methoxy-benzoyl chloride 
• 14271-83-1 4-methoxybenzoyl cyanide 
• 86399-73-7 N,O-bis-(4-methoxy-benzoyl)-N-phenyl-hydroxylamine 

Downstream Products

• 1151-93-5 4-(N,N-dimethylamino)-4'-methoxybenzophenone 
• 104689-69-2 (4-(diethylamino)phenyl)(4-methoxyphenyl)methanone 
• 38968-72-8 N-phenyl-(4-methoxypheny)acetimidoyl chloride 
• 5866-79-5 (4-Methoxy-benzoyl)-phenyl-carbamic acid isopropyl ester 
• 68823-22-3 2-(4-methoxy-phenyl)-4,6-dioxo-3,5-diphenyl-5,6-dihydro-4H-[1,3]oxazinium betaine 
• 154822-32-9 3-hydroxy-3-(pyridin-4-yl)-5-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one 
• 154822-28-3 3-hydroxy-3-(pyridin-2-yl)-5-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one 
• 147637-14-7 3-hydroxy-5-methoxy-2-chphenyl-2,3-dihydro-1H-isoindol-1-one 
• 28281-58-5 7-methoxyisobenzofuran-1(3H)-one 
• 100990-66-7 4-methoxy-N-(4-(4-methoxybenzamido)phenyl)-N-phenylbenzamide 
• 26060-23-1 4-methoxy-N-phenylthiobenzamide 
• 748164-68-3 3-(2'-methoxyphenyl)-5-methoxy-1-isobenzofuranone 
• 221632-75-3 3-hydroxy-3-(pyridin-3-yl)-5-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one 
• 259817-06-6 ethyl 2-diazo-3-[N-(4-methoxybenzoyl)-N-phenylamino]-3-oxopropanoate 

Relevant articles and documents

Cobalt-Catalyzed Deoxygenative Hydroboration of Nitro Compounds and Applications to One-Pot Synthesis of Aldimines and Amides

The commercially available and bench-stable Co(acac)2 ligated with bis[(2-diphenylphosphino)phenyl] ether (dpephos) was employed for selective room temperature hydroboration of nitro compounds with HBPin (TOF up to 4615 h?1), tolerating halide, hydroxy, amino, ether, ester, lactone, amide and heteroaromatic functionalities. These reactions offered a direct access to a variety of N-borylamines RN(H)BPin, which were in situ treated with aldehydes and carboxylic acids to produce a series of aldimines and secondary carboxamides without the need for dehydrating and/or coupling reagents. Combination of these transformations in a sequential one-pot manner allowed for direct and selective synthesis of aldimines and secondary carboxamides from readily available and inexpensive nitro compounds.

Nickel-Catalyzed Reductive Cross-Coupling of N-Acyl and N-Sulfonyl Benzotriazoles with Diverse Nitro Compounds: Rapid Access to Amides and Sulfonamides

Herein we report a Ni-catalyzed reductive transamidation of conveniently available N-acyl benzotriazoles with alkyl, alkenyl, and aryl nitro compounds, which afforded various amides with good yields and a broad substrate scope. The same catalytic reaction conditions were also applicable for N-sulfonyl benzotriazoles, which could undergo smooth reductive coupling with nitroarenes and nitroalkanes to afford the corresponding sulfonamides.

Palladium-Catalyzed Desulfurative Hiyama Coupling of Thioureas to Achieve Amides via Selective C-N Bond Cleavage

Palladium-catalyzed Hiyama coupling of active thioureas via selective C-N bond cleavage is reported. Notably, the new approach employed active thioureas as coupling partners in the presence of arylsilanes to give amides in good yield. Further, this strategy, which utilized CuF 2as a key oxidant and activator, afforded various amide products under mild conditions and an easy to handle procedure without extra base.