1211534-27-8 Usage
Description
5-Fluoro-2-Methoxy-3-nitropyridine is a chemical compound with the molecular formula C6H5FN2O3. It is a nitro derivative of pyridine that contains a fluorine atom and a methoxy group. This yellow crystalline solid is primarily used in the synthesis of pharmaceuticals and agrochemicals, and also serves as an intermediate in the production of various organic compounds. Furthermore, it is recognized for its potential as a building block in the development of new materials and chemical products. However, due to its potential hazardous properties, careful handling is required.
Uses
Used in Pharmaceutical Industry:
5-Fluoro-2-Methoxy-3-nitropyridine is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Fluoro-2-Methoxy-3-nitropyridine is utilized as a precursor in the production of agrochemicals, which are essential for crop protection and enhancement of agricultural yields.
Used in Organic Compounds Production:
5-Fluoro-2-Methoxy-3-nitropyridine is used as an intermediate in the synthesis of a range of organic compounds, facilitating the creation of diverse chemical products for various applications.
Used in Material and Chemical Product Development:
5-Fluoro-2-Methoxy-3-nitropyridine is also used as a building block in the development of new materials and chemical products, indicating its versatility and potential for innovation in the chemical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 1211534-27-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,1,5,3 and 4 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1211534-27:
(9*1)+(8*2)+(7*1)+(6*1)+(5*5)+(4*3)+(3*4)+(2*2)+(1*7)=98
98 % 10 = 8
So 1211534-27-8 is a valid CAS Registry Number.
1211534-27-8Relevant articles and documents
Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases
Bach, Jordi,Eastwood, Paul,González, Jacob,Gómez, Elena,Alonso, Juan Antonio,Fonquerna, Silvia,Lozoya, Estrella,Orellana, Adela,Maldonado, Mónica,Calaf, Elena,Albertí, Joan,Pérez, Juan,Andrés, Ana,Prats, Neus,Carre?o, Cristina,Calama, Elena,De Alba, Jorge,Calbet, Marta,Miralpeix, Montserrat,Ramis, Isabel
supporting information, p. 9045 - 9060 (2019/11/03)
Janus kinases (JAKs) have a key role in regulating the expression and function of relevant inflammatory cytokines involved in asthma and chronic obstructive pulmonary disease. Herein are described the design, synthesis, and pharmacological evaluation of a series of novel purinone JAK inhibitors with profiles suitable for inhaled administration. Replacement of the imidazopyridine hinge binding motif present in the initial compounds of this series with a pyridone ring resulted in the mitigation of cell cytotoxicity. Further systematic structure-activity relationship (SAR) efforts driven by structural biology studies led to the discovery of pyridone 34, a potent pan-JAK inhibitor with good selectivity, long lung retention time, low oral bioavailability, and proven efficacy in the lipopolysaccharide-induced rat model of airway inflammation by the inhaled route.
Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases
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Page/Page column 22, (2012/12/13)
New pyridin-2(1h)-one derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).