136888-20-5

Basic information

• Product Name: 5-FLUORO-2-HYDROXY-3-NITROPYRIDINE
• Synonyms: 5-FLUORO-2-HYDROXY-3-NITROPYRIDINE;2-hydroxy-3-nitro-5-fluoropyridine;2-hydroxy-5-fluoro-3-nitropyridine;5-bromo-2-methoxynicotinaldehyde;5-fluoro-3-nitropyridin-2-ol;5-fluoro-2-hydroxy-3-nitrop;5-fluoro-3-nitro-2-hydroxypyridine;5-Fluoro-3-nitropyridin-2(1H)-one
• CAS NO: 136888-20-5
• Molecular Formula: C₅H₃FN₂O₃
• Molecular Weight: 158.09
• Product Categories: Pyridine;Pyridines;Fluorine series
• Mol File: 136888-20-5.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 314.614 °C at 760 mmHg
• Flash Point: 144.074 °C
• Appearance: /Solid
• Density: 1.627g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: Room temperature.
• PKA: 6.43±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 5-FLUORO-2-HYDROXY-3-NITROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-2-HYDROXY-3-NITROPYRIDINE(136888-20-5)
• EPA Substance Registry System: 5-FLUORO-2-HYDROXY-3-NITROPYRIDINE(136888-20-5)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 26-36/37
• Hazardous Substances Data: 136888-20-5(Hazardous Substances Data)

Usage

Uses

It is used as a pharmaceutical intermediate.

InChI:InChI=1/C5H3FN2O3/c6-3-1-4(8(10)11)5(9)7-2-3/h1-2H,(H,7,9)

Upstream product

• 51173-05-8 5-fluoropyridin-2-ol 
• 51173-05-8 5-fluoropyridin-2(1H)-one 
• 6628-77-9 6-methoxy-pyridin-3-ylamine 
• 51173-04-7 5-fluoro-2-methoxypyridine 

Downstream Products

• 136888-21-6 2-chloro-5-fluoro-3-nitro pyridine 
• 136888-22-7 6-fluoro-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one 
• 652160-72-0 2-bromo-5-fluoro-3-nitropyridine 
• 1383051-06-6 5-fluoro-3-nitropyridin-2-yl 4-methylbenzenesulfonate 
• 1404085-49-9 5-fluoro-3-nitro-N-phenylpyridin-2-amine 
• 1211541-93-3 5-fluoro-2-methoxy-pyridin-3-amine 
• 1211534-27-8 5-fluoro-2-methoxy-3-nitropyridine 
• 446284-38-4 7-bromo-4-fluoro-1H-pyrrolo[2,3-c]pyridine 
• 959321-16-5 C₂₂H₂₀FN₅O₄ 
• 959321-17-6 C₂₁H₁₈FN₅O₄ 
• 446290-68-2 C₂₃H₁₈FN₅O₄ 
• 446290-66-0 C₂₃H₁₈FN₅O₄ 
• 446288-45-5 1-benzoyl-4-[(4-fluoro-7-(pyrazol-3-yl)-6-azaindol-3-yl)-oxoacetyl]piperazine 
• 619331-06-5 C₂₄H₂₀FN₇O₄ 

Relevant articles and documents

Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases

Janus kinases (JAKs) have a key role in regulating the expression and function of relevant inflammatory cytokines involved in asthma and chronic obstructive pulmonary disease. Herein are described the design, synthesis, and pharmacological evaluation of a series of novel purinone JAK inhibitors with profiles suitable for inhaled administration. Replacement of the imidazopyridine hinge binding motif present in the initial compounds of this series with a pyridone ring resulted in the mitigation of cell cytotoxicity. Further systematic structure-activity relationship (SAR) efforts driven by structural biology studies led to the discovery of pyridone 34, a potent pan-JAK inhibitor with good selectivity, long lung retention time, low oral bioavailability, and proven efficacy in the lipopolysaccharide-induced rat model of airway inflammation by the inhaled route.

Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases

New pyridin-2(1h)-one derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

TRIAZOLE DERIVATIVES AS VASOPRESSIN ANTAGONISTS

Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R1 represents a group selected from H, CF3, and C1-6 alkyl (optionally substituted by C1-6 alkyloxy or triazolyl); R2/