121195-62-8Relevant articles and documents
A New Synthesis of some Indolecarboxylic Acids
Baiocchi, Leandro,Giannangeli, Marilena
, p. 1905 - 1909 (2007/10/02)
1-Substituted isatins are transformed into indole derivatives by means of ethyl chloroacetate.In fact, under the conditions of the Darzens reaction they give two glycidic ester isomers 4 and 5 which, by hydrolysis in alkaline medium, undergo a transposition to indole-2,3-dicarboxylic acids 2 together with minor amounts of indole-3-carboxylic acids 3.From isatin itself, 2,3-dicarboxyindole-1-acetic acid (6) was obtained.