723-89-7

Basic information

• Product Name: 1-PHENYLISATIN
• Synonyms: 1H-Indole-2,3-dione, 1-phenyl-;1-Phenyl-indole-2,3-dione;1-phenyl-indole-3-dione;1-PHENYL-1H-INDOLE-2,3-DIONE;1-PHENYLISATIN;N-PHENYLISATIN;1-Phenylisatine;1-Phenylisatin,98%
• CAS NO: 723-89-7
• Molecular Formula: C₁₄H₉NO₂
• Molecular Weight: 223.23
• EINECS: -0
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Indoles
• Mol File: 723-89-7.mol
• Article Data: 78

Chemical Properties

• Melting Point: 138-140 °C(lit.)
• Boiling Point: 388.8°C at 760 mmHg
• Flash Point: 182.6°C
• Appearance: /
• Density: 1.338g/cm³
• Vapor Pressure: 2.99E-06mmHg at 25°C
• Refractive Index: 1.667
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -7.03±0.20(Predicted)
• Water Solubility: Insoluble in water.
• BRN: 164531
• CAS DataBase Reference: 1-PHENYLISATIN(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYLISATIN(723-89-7)
• EPA Substance Registry System: 1-PHENYLISATIN(723-89-7)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25
• Safety Statements: 27-28-36/37/39-45
• WGK Germany: 3
• RTECS: NL7984000
• HazardClass: IRRITANT
• Hazardous Substances Data: 723-89-7(Hazardous Substances Data)

Usage

Uses

1-Phenylisatin is a reactant for preparation of indolin-2,3-dione Schiff bases as potential antimycobacterial agents, antipyretic agents, antiproliferative agents, phenylacetamides as anticonvulsant agents and selective Galanin GAL3 receptor antagonists.

General Description

1-Phenylisatin is an isatin. It is a potential anticancer, anti-HIV drug. Its binding interaction with a model transport protein bovine serum albumin (BSA) has been investigated using fluorescence spectroscopic technique. Interactions between human adult hemoglobin (Hb) and 1-phenylisatin has been investigated by steady state and time-resolved fluorescence along with circular dichroism (CD) spectroscopic, FTIR and anisotropy.

InChI:InChI=1/C14H9NO2/c16-13-11-8-4-5-9-12(11)15(14(13)17)10-6-2-1-3-7-10/h1-9H

Upstream product

• 51838-06-3 3-(N,N-diphenylamino)-3-oxopropanenitrile 
• 75385-92-1 (N,N-diphenylcarbamoyl) formyl chloride 
• 81254-05-9 1-Phenyl-3-nitroso-4-hydroxycarbostyryl 
• 108-86-1 bromobenzene 
• 91-56-5 indole-2,3-dione 
• 603-33-8 triphenylbismuthane 
• 412284-37-8 1-phenyl-indol-3-ol 
• 64-17-5 ethanol 
• 7705-08-0 iron(III) chloride 
• 64-19-7 acetic acid 
• 7697-37-2 nitric acid 
• 631900-36-2 1,1'-diphenyl-1H,1'H-[2,2']biindolylidene-3,3'-dione 
• 58386-33-7 1-phenylindole-2-carboxylic acid 
• 934-56-5 trimethyl(phenyl)stannane 

Downstream Products

• 124145-27-3 N-phenyl-1,3-dihydro-3,3-diphenyl-2H-indol-2-one 
• 303984-71-6 1-phenyl-indoline-2,3-dione-3-phenylhydrazone 
• 93717-59-0 3-hydroxy-1-phenylindolin-2-one 
• 859068-29-4 3,3-dichloro-1-phenylindolin-2-one 
• 105431-71-8 1,3-dihydro-3-hydroxy-1-phenyl-3-(pyridinylmethyl)-2H-indol-2-one 
• 121195-62-8 1-phenylindole-2,3-dicarboxylic acid 
• 25854-97-1 N-Nitrozo-N-phenyl-anthranilic acid 
• 87885-91-4 C₂₆H₁₈N₄O₃ 
• 28561-80-0 3-hydroxy-1-phenyl-1H-indazole 
• 20877-86-5 N-phenyl isatoic anhydride 

Relevant articles and documents

PROTECTIVE EFFECTS OF ISATINS IN HYPOBARIC HYPOXIA

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Palladium catalyzed divergent cycloadditions of vinylidenecyclopropane-diesters with methyleneindolinones enabled by zwitterionic π-propargyl palladium species

A palladium-catalyzed divergent synthesis of spirooxindoles fused with a five- or a six-membered ring by a cycloaddition reaction of vinylidenecyclopropane-diesters with methyleneindolinones was disclosed. This protocol features anin situgenerated unprecedented zwitterionic π-propargyl palladium species in cycloaddition reactions and a switchable process between (3+2) and (4+2) cycloadditions by changing the phosphine ligand.

Catalytic Asymmetric Addition of Diorganozinc Reagents to Pyrazole-4,5-Diones and Indoline-2,3-Diones

The catalytic enantioselective diorganozinc additions to cyclic diketones including pyrazolin-4,5-diones and isatins have been developed. In the presence of morpholine-containing chiral amino alcohol ligand, the corresponding chiral cyclic tertiary alcohols were produced in good to excellent yields (up to 97 %) and enantioselectivities (up to 95 % ee). The notable feature of this protocol includes its mild reaction conditions, Lewis acid additives free and broad functional group tolerance.