121225-05-6

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 3-[(1E)-3-(2-hydroxy-5-methylphenyl)-3-oxo-1-propenyl]-6-methyl-
• CAS NO: 121225-05-6
• Molecular Formula: C20H16O4
• Molecular Weight: 320.345
• Mol File: 121225-05-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 3-[(1E)-3-(2-hydroxy-5-methylphenyl)-3-oxo-1-propenyl]-6-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 3-[(1E)-3-(2-hydroxy-5-methylphenyl)-3-oxo-1-propenyl]-6-methyl-(121225-05-6)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 3-[(1E)-3-(2-hydroxy-5-methylphenyl)-3-oxo-1-propenyl]-6-methyl-(121225-05-6)

Safety Data

• Hazardous Substances Data: 121225-05-6(Hazardous Substances Data)

Upstream product

• 68723-78-4 6-methyl-4-oxo-4H-chromene-3-carboxylic acid 
• 42059-81-4 3-formyl-6-methylchromone 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 68-12-2 N,N-dimethyl-formamide 
• 90617-36-0 2,3-dihydro-2-hydroxy-6-methyl-1-benzopyran-4-one 

Relevant articles and documents

Synthesis and Antimicrobial Activity of (Z)-3-{[3-Oxobenzofuran-2(3H)-ylidene]methyl}-4H-chromen-4-one Derivatives

A series of (Z)-3-{[3-oxobenzofuran-2(3H)-ylidene]methyl}-4H-chromen-4-one derivatives have been synthesized from 2-hydroxyl acetophenones by the Vilesmeier–Haack reaction, Claisen–Schmidt reaction and mercury(II) acetate/cupric bromide. All the synthesized compounds were characterized by IR, 1H and 13C NMR, and mass spectral data and elemental analysis. The products were tested for their in vitro antimicrobial activity.

Behaviour of o-hydroxyacetophenones towards action of POCl3/DMF (Vilsmeier reagent) in presence of BF3.Et2O: A novel observation in the synthesis of chromones

The influence of the presence of BF3.Et2O on the Vilsmeier reactions of o-hydroxyacetophenones and related naphthophenones has been examined. A significant and novel feature of this study is the development of new and facile procedure for the synthesis of some chromones. The reaction offers a first example of monoformylation of o-hydroxyacetophenones.

Thermal Dimerization of 2-Hydroxychromanones to 1-(2-Hydroxybenzoyl)-2-(4-oxo-4H-1-benzopyran-3-yl)ethylene Derivatives: An Unusual Observation

o-Hydroxyacetophenone derivatives on condensation with ethyl formate in the presence of sodium give the corresponding 2-hydroxychromanones (I), which when heated above their melting points afford 1-(2-hydroxybenzoyl)-2-(4-oxo-4H-1-benzopyran-3-yl)ethylene