68723-78-4

Basic information

• Product Name: 6-METHYLCHROMONE-3-CARBOXYLIC ACID
• Synonyms: 6-METHYLCHROMONE-3-CARBOXYLIC ACID;6-METHYL-4-OXO-4H-CHROMENE-3-CARBOXYLIC ACID;RARECHEM AL BO 1386
• CAS NO: 68723-78-4
• Molecular Formula: C₁₁H₈O₄
• Molecular Weight: 204.18
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 68723-78-4.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-METHYLCHROMONE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHYLCHROMONE-3-CARBOXYLIC ACID(68723-78-4)
• EPA Substance Registry System: 6-METHYLCHROMONE-3-CARBOXYLIC ACID(68723-78-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 68723-78-4(Hazardous Substances Data)

Usage

General Description

6-Methylchromone-3-carboxylic acid is a chemical compound belonging to the chromone family, with a molecular formula of C11H8O4. It is a derivative of chromone and is commonly used in the pharmaceutical industry for the synthesis of various pharmaceuticals and biological compounds. 6-METHYLCHROMONE-3-CARBOXYLIC ACID has shown potential as an anti-inflammatory, antiviral, and antibacterial agent, making it a subject of interest in drug development. Its unique structure and biological activities have made it a target for further research and investigation for its potential therapeutic applications.

Upstream product

• 38445-23-7 6-methyl-chromen-4-one 
• 124-38-9 carbon dioxide 
• 42059-81-4 3-formyl-6-methylchromone 
• 755009-11-1 C₁₂H₁₁NO₃ 
• 755009-10-0 C₁₃H₁₃NO₃ 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 

Downstream Products

• 68723-75-1 8-methyl-2-phenyl-2H-chromeno[4,3-c]pyrazol-3-one 
• 80031-00-1 (E)-1-(2-hydroxy-5-methylphenyl)-3-(piperidin-1-yl)prop-2-en-1-one 
• 126214-23-1 4-hydroxy-6-methyl-2-oxo-2H-1-benzopyran-3-carboxaldehyde 
• 38445-23-7 6-methyl-chromen-4-one 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 90617-36-0 2,3-dihydro-2-hydroxy-6-methyl-1-benzopyran-4-one 
• 121225-05-6 3-[(E)-3-(2-hydroxy-5-methylphenyl)-3-oxoprop-1-enyl]-6-methyl-4H-chromen-4-one 

Relevant articles and documents

Chromone 3-position nitric oxide donor derivative as well as preparation method and application thereof

The invention relates to the fields of natural medicines and medicinal chemistry, and relates to a preparation method of a series of chromone 3-position nitric oxide donor derivatives with antitumor activity and a new application of the chromone 3-position nitric oxide donor derivatives in preparation of antitumor medicines. The chromone 3-position nitric oxide donor derivative and the pharmaceutically acceptable salt thereof are shown as a general formula I in the specification. Wherein R and R1 are described in the claims and the specification.

Chromone 2-position nitric oxide donor derivative as well as preparation method and application thereof

The invention relates to the fields of natural medicines and medicinal chemistry, and relates to a preparation method of a series of chromone 2-position nitric oxide donor derivatives with antitumor activity and a new application of the chromone 2-position nitric oxide donor derivatives in preparation of antitumor medicines. The chromone 2-position nitric oxide donor derivative and the pharmaceutically acceptable salt thereof are shown as a general formula I in the specification. Wherein R and R1 are described in the claims and the specification.

Antiproliferative chromone derivatives induce K562 cell death through endogenous and exogenous pathways

A series of furoxan derivatives of chromone were prepared. The antiproliferative activities were tested against five cancer cell lines HepG2, MCF-7, HCT-116, B16, and K562, and two normal human cell lines L-02 and PBMCs. Among them, compound 15a exhibited the most potent antiproliferative activity. It was also found 15a produced more than 8 μM of NO at the peak time of 45 min by Griess assay. Generally, antiproliferative activity is positively related to NO release to some extent. Further in-depth studies on apoptosis-related mechanisms showed that 15a caused S-phase cell cycle arrest in a concentration-dependent manner and induced apoptosis significantly through mitochondria-related pathways. Human apoptosis protein array assay also demonstrated 15a increased the expression levels of pro-apoptotic Bax, Bad, HtrA2 and Trail R2/DR5. The expression of catalase and cell cycle blocker claspin were similarly up-regulated. In balance, 15a induced K562 cells death through both endogenous and exogenous pathways.