1217184-20-7

Basic information

• Product Name: 7-chloro-2,9-diphenyl-2,3-dihydrothieno[3,2-b]quinoline
• Synonyms: 7-chloro-2,9-diphenyl-2,3-dihydrothieno[3,2-b]quinoline
• CAS NO: 1217184-20-7
• Molecular Weight: 373.906
• Mol File: 1217184-20-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-chloro-2,9-diphenyl-2,3-dihydrothieno[3,2-b]quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-2,9-diphenyl-2,3-dihydrothieno[3,2-b]quinoline(1217184-20-7)
• EPA Substance Registry System: 7-chloro-2,9-diphenyl-2,3-dihydrothieno[3,2-b]quinoline(1217184-20-7)

Safety Data

• Hazardous Substances Data: 1217184-20-7(Hazardous Substances Data)

Upstream product

• 36748-19-3 4,5-dihydro-5-phenyl-3(2H)-thiophenone 
• 719-59-5 5-chloro-2-aminobenzophenone 

Relevant articles and documents

A microwave-assisted, facile, regioselective Friedl?nder synthesis and antitubercular evaluation of 2,9-diaryl-2,3-dihydrothieno-[3,2-b]quinolines

A series of 2,9-diaryl-2,3-dihydrothieno[3,2-b]quinolines have been synthesized regioselectively by Friedl?nder annulation of 5-aryldihydro-3(2H)-thiophenones and 2-aminobenzophenones in the presence of trifluoroacetic acid in good yields under microwave irradiation at 100?°C. The 2,9-diaryl-2,3-dihydrothieno[3,2-b]quinolines were screened for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv (MTB) and multi-drug resistant M. tuberculosis (MDR-TB). Among the 17 compounds screened, 7-chloro-2-(2,4-dichlorophenyl)-9-phenyl-2,3-dihydrothieno-[3,2-b]quinoline and 7-chloro-2-(3-nitrophenyl)-9-phenyl-2,3-dihydrothieno[3,2-b]quinoline display maximum activity with MIC of 0.90 and 0.95?μM against MTB and MDR-TB respectively.