36748-19-3

Basic information

• Product Name: 3(2H)-Thiophenone, dihydro-5-phenyl-
• CAS NO: 36748-19-3
• Molecular Formula: C10H10OS
• Molecular Weight: 178.255
• Mol File: 36748-19-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3(2H)-Thiophenone, dihydro-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Thiophenone, dihydro-5-phenyl-(36748-19-3)
• EPA Substance Registry System: 3(2H)-Thiophenone, dihydro-5-phenyl-(36748-19-3)

Safety Data

• Hazardous Substances Data: 36748-19-3(Hazardous Substances Data)

Upstream product

• 106167-58-2 3-oxo-5-phenyl-tetrahydro-thiophene-2-carboxylic acid methyl ester 
• 80278-80-4 3-oxo-5-phenyltetrahydrothiophen-2-ethylcarboxylate 
• 38293-64-0 ethyl 2-phenyl-4-oxothiolane-3-carboxylate 
• 4192-77-2 ethyl cinnamate 
• 82617-90-1 2-chloroacetyl-3-phenyl-acrylic acid ethyl ester 
• 100-52-7 benzaldehyde 
• 67242-91-5 3-[(carboxymethyl)thio]-3-phenylpropanoic acid 
• 140-10-3 (E)-3-phenylacrylic acid 
• 68-11-1 mercaptoacetic acid 

Downstream Products

• 75782-80-8 4,5-dihydro-5-phenyl-3(2H)-thiophenone oxime 
• 177540-95-3 (5-phenylthiophen-3-yl)acetonitrile 
• 197781-25-2 5-Methoxy-6-methoxymethyl-4-(2-phenyltetrahydrothiophen-4-ylamino)pyrimidine 
• 1171818-70-4 2-phenyl-3,4-dihydro-2H-thieno[3,2-b]indole 
• 1171818-79-3 7-chloro-2-phenyl-3,4-dihydro-2H-thieno[3,2-b]indole 
• 1171818-86-2 7-fluoro-2-phenyl-3,4-dihydro-2H-thieno[3,2-b]indole 
• 1428258-96-1 C₂₃H₁₇N₃S 
• 1428258-97-2 C₂₃H₁₇N₃OS 
• 1428258-98-3 C₂₂H₁₄ClN₃S 
• 1428258-99-4 C₂₂H₁₄FN₃S 
• 1428259-00-0 C₂₂H₁₄BrN₃S 
• 1428259-01-1 C₂₅H₂₁N₃S 
• 17517-73-6 2,9-diphenyl-2,3-dihydrothieno[3,2-b]quinoline 
• 1217184-20-7 7-chloro-2,9-diphenyl-2,3-dihydrothieno[3,2-b]quinoline 

Relevant articles and documents

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5-(Phenylthiophene)-3-carboxylic acid (2a), a metabolite of esonarimod (1), which was developed as a new antirheumatic drug, was considered as a lead compound for new antirheumatic drugs. A new series of 2a derivatives were synthesized and their characteristic pharmacological effects, that is their antagonistic effect toward interleukin (IL)-1 in mice and the suppressive effect against adjuvant-induced arthritis (AIA) in rats, were evaluated and compared with those of 1. The structure-activity relationships indicated that [5-(4-bromophenyl)-thiophen-3-yl]acetic acid (5d), methyl [5-(4-chlorophenyl)-thiophen-3-yl]acetate (5h), and methyl [5-(4-bromophenyl)-thiophen-3-yl]acetate (5i) suppressed AIA more potently than 1 and all of the other synthesized compounds.