1428258-99-4

Basic information

• Product Name: C₂₂H₁₄FN₃S
• Synonyms: C₂₂H₁₄FN₃S
• CAS NO: 1428258-99-4
• Molecular Weight: 371.438
• Mol File: 1428258-99-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₄FN₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₄FN₃S(1428258-99-4)
• EPA Substance Registry System: C₂₂H₁₄FN₃S(1428258-99-4)

Safety Data

• Hazardous Substances Data: 1428258-99-4(Hazardous Substances Data)

Upstream product

• 36748-19-3 4,5-dihydro-5-phenyl-3(2H)-thiophenone 
• 459-57-4 4-fluorobenzaldehyde 
• 109-77-3 malononitrile 

Relevant articles and documents

A one-pot domino synthesis and discovery of highly functionalized dihydrobenzo[b]thiophenes as AChE inhibitors

A library of novel 5-amino-2,7-diaryl-2,3-dihydrobenzo[b]thiophene-4,6- dicarbonitriles have been synthesized regioselectively in good yields through the one-pot domino reactions of 5-aryldihydro-3(2H)-thiophenones, malononitrile and aromatic aldehydes in the presence of morpholine. This transformation presumably involves Knoevenagel condensation-Michael addition-intramolecular Thorpe-Ziegler cyclization-Tautomerization-Elimination sequence of reactions. These compounds were evaluated for their acetylcholinesterase (AChE) inhibitory activity and 5-amino-2,7-bis(4-methoxyphenyl)-2,3-dihydrobenzo[b]thiophene-4,6- dicarbonitrile was found to be the most potent against AChE with IC50 4.16 μmol/L.