122023-36-3

Basic information

• Product Name: 2-bromo-2-phenyl-1-(4-(trifluoromethyl)phenyl)ethan-1-one
• Synonyms: 2-bromo-2-phenyl-1-(4-(trifluoromethyl)phenyl)ethan-1-one
• CAS NO: 122023-36-3
• Molecular Weight: 343.143
• Mol File: 122023-36-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-bromo-2-phenyl-1-(4-(trifluoromethyl)phenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-2-phenyl-1-(4-(trifluoromethyl)phenyl)ethan-1-one(122023-36-3)
• EPA Substance Registry System: 2-bromo-2-phenyl-1-(4-(trifluoromethyl)phenyl)ethan-1-one(122023-36-3)

Safety Data

• Hazardous Substances Data: 122023-36-3(Hazardous Substances Data)

Upstream product

• 2967-66-0 methyl 4-(trifluoromethyl)benzoate 
• 61062-55-3 2-phenyl-1-(4-(trifluoromethyl)phenyl)ethan-1-one 

Downstream Products

• 1187925-46-7 4-phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-amine 

Relevant articles and documents

Ketone Synthesis from Benzyldiboronates and Esters: Leveraging α-Boryl Carbanions for Carbon-Carbon Bond Formation

An alkoxide-promoted method for the synthesis of ketones from readily available esters and benzyldiboronates is described. The synthetic method is compatible with a host of sterically differentiated alkyl groups, alkenes, acidic protons α to carbonyl groups, tertiary amides, and aryl rings having common organic functional groups. With esters bearing α-stereocenters, high enantiomeric excess was maintained during ketone formation, establishing minimal competing racemization by deprotonation. Monitoring the reaction between benzyldiboronate and LiOtBu in THF at 23 °C allowed for the identification of products arising from deborylation to form an α-boryl carbanion, deprotonation, and alkoxide addition to form an "-ate" complex. Addition of 4-trifluoromethylbenzoate to this mixture established the α-boryl carbanion as the intermediate responsible for C-C bond formation and ultimately ketone synthesis. Elucidation of the role of this intermediate leveraged additional bond-forming chemistry and enabled the one-pot synthesis of ketones with α-halogen atoms and quaternary centers with four-different carbon substituents.

UREIDE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES

This invention relates to a pharmaceutical comprising, as an active ingredient, a ureide derivative represented by formula: or a pharmaceutically acceptable salt thereof. The ureide derivative or a pharmaceutically acceptable salt thereof according to the present invention is useful for relieving pain and treating or preventing neuropathic pain.