61062-55-3

Basic information

• Product Name: 2-PHENYL-4'-TRIFLUOROMETHYLACETOPHENONE
• Synonyms: 2-PHENYL-4'-TRIFLUOROMETHYLACETOPHENONE
• CAS NO: 61062-55-3
• Molecular Formula: C₁₅H₁₁F₃O
• Molecular Weight: 264.24
• Mol File: 61062-55-3.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 343.4 °C at 760 mmHg
• Flash Point: 175.4 °C
• Appearance: /
• Density: 1.228g/cm³
• Vapor Pressure: 7.04E-05mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly, Sonicated)
• CAS DataBase Reference: 2-PHENYL-4'-TRIFLUOROMETHYLACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-4'-TRIFLUOROMETHYLACETOPHENONE(61062-55-3)
• EPA Substance Registry System: 2-PHENYL-4'-TRIFLUOROMETHYLACETOPHENONE(61062-55-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 61062-55-3(Hazardous Substances Data)

Usage

Description

2-PHENYL-4'-TRIFLUOROMETHYLACETOPHENONE is an organic compound with the molecular formula C15H11F3O. It is a derivative of acetophenone, featuring a phenyl group and a trifluoromethyl group attached to the molecule. 2-PHENYL-4'-TRIFLUOROMETHYLACETOPHENONE is known for its unique chemical properties and potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
2-PHENYL-4'-TRIFLUOROMETHYLACETOPHENONE is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of organic chemistry, 2-PHENYL-4'-TRIFLUOROMETHYLACETOPHENONE is used as a building block for the synthesis of complex organic molecules. Its reactivity and functional groups make it a valuable component in the creation of new chemical entities.
Used in Material Science:
2-PHENYL-4'-TRIFLUOROMETHYLACETOPHENONE can be utilized in the development of advanced materials, such as polymers and coatings, due to its unique chemical properties. Its incorporation into these materials can lead to improved performance characteristics, such as enhanced stability and durability.
Used in the Preparation of Arylketones:
2-PHENYL-4'-TRIFLUOROMETHYLACETOPHENONE is used as a key component in the preparation of arylketones via palladium-tedicyp-catalyzed Heck reaction. This reaction is an important synthetic method for constructing carbon-carbon bonds, which are essential in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and advanced materials.

InChI:InChI=1/C15H11F3O/c16-15(17,18)13-8-6-12(7-9-13)14(19)10-11-4-2-1-3-5-11/h1-9H,10H2

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 100-39-0 benzyl bromide 
• 908094-04-2 phenyldiazomethane 
• 4747-15-3 1-(2-methoxyvinyl)benzene 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 201230-82-2 carbon monoxide 
• 100-44-7 benzyl chloride 
• 455-13-0 4-Iodobenzotrifluoride 
• 62673-31-8 benzyl(bromo)zinc 
• 13939-06-5 molybdenum hexacarbonyl 
• 1539-57-7 diethyl 2,6-dimethyl-4-benzyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 108-86-1 bromobenzene 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 

Downstream Products

• 35923-45-6 1-phenyl-2-(4-(trifluoromethyl)phenyl)ethane-1,2-dione 
• 122023-36-3 2-bromo-2-phenyl-1-(4-(trifluoromethyl)phenyl)ethan-1-one 
• 1283118-42-2 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5-phenyl-6-(4-(trifluoromethyl)phenyl)-3,4-dihydropyrimidin-2(1H)-one 
• 347-80-8 N-phenyl 4-trifluoromethylbenzamide 
• 100-52-7 benzaldehyde 
• 441-36-1 2-benzyl-4'-trifluoromethyl-benzophenone 

Relevant articles and documents

Preparation method of aryl ketone

The invention discloses a preparation method of aryl ketone. The preparation method comprises the following steps: mixing a phenyl epoxy compound, aryl trifluoromethanesulfonate, a phosphine ligand, a nickel source, alkali and an organic solvent, and conducting reacting in one step under the protection of inert gas to generate aryl ketone. The preparation method disclosed by the invention is simple in process, mild in conditions and low in cost, and paves a way for large-scale industrial production application, such as drug synthesis or natural product synthesis application, of aryl ketone serving as an important organic reaction intermediate.

The organocatalytic enantiodivergent fluorination of β-ketodiaryl-phosphine oxides for the construction of carbon-fluorine quaternary stereocenters

Commercially available cinchona alkaloids that can catalyze the enantiodivergent fluorination of β-ketodiarylphosphine oxides were developed to construct carbon-fluorine quaternary stereocenters. This protocol features a wide scope of substrates and excellent enantioselectivities, and it is scalable.

Aerobic oxygenation of α-methylene ketones under visible-light catalysed by a CeNi3complex with a macrocyclic tris(salen)-ligand

A hetero-tetranuclear CeNi3 complex with a macrocyclic ligand catalysed the aerobic oxygenation of a methylene group adjacent to a carbonyl group under visible-light radiation to produce the corresponding α-diketones. The visible-light induced homolysis of the Ce-O bond of a bis(enolate) intermediate is proposed prior to aerobic oxygenation.