122148-91-8

Basic information

• Product Name: 4-cyanophenyl thiocyanate
• Synonyms: 4-cyanophenyl thiocyanate
• CAS NO: 122148-91-8
• Molecular Weight: 160.199
• Mol File: 122148-91-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4-cyanophenyl thiocyanate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-cyanophenyl thiocyanate(122148-91-8)
• EPA Substance Registry System: 4-cyanophenyl thiocyanate(122148-91-8)

Safety Data

• Hazardous Substances Data: 122148-91-8(Hazardous Substances Data)

Upstream product

• 540-72-7 sodium thiocyanide 
• 2252-32-6 4-cyanophenyldiazonium tetrafluoroborate 
• 873-74-5 4-Aminobenzonitrile 
• 1111-67-7 copper(I) thiocyanate 
• 2290-65-5 trimethylsilyl isothiocyanate 
• 126747-14-6 4-cyanophenylboronic acid 
• 2987-46-4 4-thiocyanatoaniline 
• 151-50-8 potassium cyanide 
• 21382-98-9 p-cyanophenyl methyl sulfide 

Downstream Products

• 4837-25-6 4-[(difluoromethyl)thio]benzonitrile 
• 332-26-3 4-[(trifluoromethyl)sulphanyl]benzenecarbonitrile 
• 207118-58-9 [2-(2-{7-[3-(4-Cyano-phenyl)-2-methyl-isothioureido]-4-methyl-2-oxo-2H-chromen-3-yl}-acetylamino)-ethyl]-carbamic acid tert-butyl ester 
• 207118-56-7 [2-(2-{7-[3-(4-Cyano-phenyl)-thioureido]-4-methyl-2-oxo-2H-chromen-3-yl}-acetylamino)-ethyl]-carbamic acid tert-butyl ester 
• 207118-52-3 {7-[3-(4-Cyano-phenyl)-thioureido]-4-methyl-2-oxo-2H-chromen-3-yl}-acetic acid 

Relevant articles and documents

Iron-Catalyzed Decarboxylation of Trifluoroacetate and Its Application to the Synthesis of Trifluoromethyl Thioethers

Nucleophilic CF3 has been generated by decarboxylation of potassium trifluoroacetate, arguably the most easy-to-handle, inexpensive, and sustainable source of trifluoromethyl groups. Simple iron(II) chloride catalyzes the decarboxylation as well as a subsequent trifluoromethylation of organothiocyanates, resulting in a straightforward synthesis of trifluoromethyl thioethers. The KCN byproduct is absorbed by iron(II) with formation of nontoxic potassium hexacyanoferrate. An analogous trifluoromethylation of aldehydes with trifluoroacetate underlines the synthetic potential of such iron-catalyzed decarboxylative trifluoromethylations.

An electrochemical method for deborylative seleno/thiocyanation of arylboronic acids under catalyst- And oxidant-free conditions

An electrochemical deborylative seleno/thiocyanation of arylboronic acids has been well established to synthesize the corresponding aryl seleno/thiocyanates with good functional group tolerance under ambient conditions. A gram-scale reaction has been performed to highlight the advantages of the protocol. Preliminary mechanistic studies indicate that the oxidation of the seleno/thiocyanate anion occurs prior to that of the arylboronic acid substrate in galvanostatic mode, and that free radicals are involved in the process.

Synthesis of difluoromethyl thioethers from difluoromethyl trimethylsilane and organothiocyanates generated in situ

A copper-CF2H complex generated in situ from copper thiocyanate and TMS-CF2H smoothly converts organothiocyanates into valuable difluoromethyl thioethers. This reaction step can be combined with several thiocyanation methods to one-pot protocols, allowing late-stage difluoromethylthiolations of widely available alkyl halides and arenediazonium salts. This strategy enables the introduction of difluoromethylthio groups - a largely unexplored substituent with highly promising properties - into drug-like molecules. A copper-CF2H complex generated in situ from copper thiocyanate and TMS-CF2H smoothly converts organothiocyanates into valuable difluoromethyl thioethers. This reaction step can be combined with several thiocyanation methods to one-pot protocols, allowing late-stage difluoromethylthiolations of widely available alkyl halides and arenediazonium salts.