122151-36-4Relevant articles and documents
INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE
-
, (2019/07/20)
The present invention provides a compound of formula (II): an inhibitor of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases. Its prodrugs are disclosed.
Streamlined, asymmetric synthesis of 8,4′-oxyneolignans
Curti, Claudio,Zanardi, Franca,Battistini, Lucia,Sartori, Andrea,Rassu, Gloria,Pinna, Luigi,Casiraghi, Giovanni
, p. 8552 - 8558 (2007/10/03)
Highly direct, modular syntheses of several natural 8,4′- oxyneolignans [(-)-1, (+)-1, (-)-2, and (-)-3] and some related variants [(-)-26, (+)-26, (+)-27, and (-)-28] are reported. Utilizing (S)- or (R)-methyl lactate as the chiral sources, two complementary syn- or anti-oriented routes were designed, encompassing nine and five steps, which were carried out to deliver the targets in an enantiomerically pure form. The embodiment of the two independent aryl and aryloxy moieties onto the lactate frame was performed according to a diversity-oriented protocol from the common precursors, aldehydes 6 and ent-6 for the syn-oriented routes and mesyl esters 19 and ent-19 for the anti-oriented routes. These syntheses set the stage for the generation of a wide and diverse repertoire of 8,4′-oxyneolignan compounds and the broad biological interrogation of its members.
Enantioselective synthesis of the C14-C25 portion of the cytotoxic natural product, amphidinolide B1
Lee, Duck-Hyung,Rho, Man-Dong
, p. 2573 - 2576 (2007/10/03)
The C14-C25 portion of the cytotoxic natural product, amphidinolide B1 (1), was synthesized enantioselectively using Myers asymmetric alkylation protocol, epoxide opening with higher order cuprate, Sharpless asymmetric epoxidation of allylic alcohol 17, a