1222504-84-8

Basic information

• Product Name: C₂₂H₁₈N₂O₂S
• CAS NO: 1222504-84-8
• Molecular Weight: 374.463
• Mol File: 1222504-84-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₈N₂O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₈N₂O₂S(1222504-84-8)
• EPA Substance Registry System: C₂₂H₁₈N₂O₂S(1222504-84-8)

Safety Data

• Hazardous Substances Data: 1222504-84-8(Hazardous Substances Data)

Upstream product

• 86268-09-9 Biphenyl-4-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide 
• 68-11-1 mercaptoacetic acid 

Downstream Products

• 1235797-14-4 biphenyl-4-carboxylic acid (5-(3-bromobenzylidene)-4-oxo-2-phenylthiazolidin-3-yl)amide 
• 1235797-13-3 biphenyl-4-carboxylic acid (5-(4-chlorobenzylidene)-4-oxo-2-phenylthiazolidin-3-yl)amide 
• 1235797-12-2 biphenyl-4-carboxylic acid (5-(3-nitrobenzylidene)-4-oxo-2-phenylthiazolidin-3-yl)amide 
• 1235797-11-1 biphenyl-4-carboxylic acid (5-benzylidene-4-oxo-2-phenylthiazolidin-3-yl)amide 
• 1235797-15-5 biphenyl-4-carboxylic acid (5-(4-methoxybenzylidene)-4-oxo-2-phenylthiazolidin-3-yl)amide 

Relevant articles and documents

Synthesis and anti-inflammatory activity of some novel biphenyl-4- carboxylic acid 5-(arylidene)-2-(aryl)-4-oxothiazolidin-3-yl amides

Some new biphenyl-4-carboxylic acid 5-(arylidene)-2-(aryl)-4- oxothiazolidin-3-yl amides have been synthesized and evaluated for anti-inflammatory activity. Biphenyl-4-carboxylic acid hydrazide was converted to the corresponding aryl hydrazones using aryl aldehydes in the presence of catalytic amount of glacial acetic acid. The aryl hydrazones on reaction with thioglycolic acid in the presence of anhydrous zinc chloride yielded the biphenyl-4-carboxylic acid 2-(aryl)-4-oxothiazolidin-3-yl amides, which again on reaction with aromatic aldehydes in the presence of anhydrous sodium acetate and glacial acetic acid furnished the title compounds. The structures of all these newly synthesized compounds were confirmed by their analytical and spectral data which were in full agreement with proposed structures. All compounds were screened for anti-inflammatory activity employing carrageenan test at the dose of 10 mg/kg and exhibited significant activities.