86268-09-9

Basic information

• Product Name: Biphenyl-4-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide
• Synonyms: Biphenyl-4-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide
• CAS NO: 86268-09-9
• Molecular Weight: 300.36
• Mol File: 86268-09-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Biphenyl-4-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Biphenyl-4-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide(86268-09-9)
• EPA Substance Registry System: Biphenyl-4-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide(86268-09-9)

Safety Data

• Hazardous Substances Data: 86268-09-9(Hazardous Substances Data)

Upstream product

• 18622-23-6 4-phenylbenzohydrazide 
• 100-52-7 benzaldehyde 

Downstream Products

• 1222504-84-8 C₂₂H₁₈N₂O₂S 
• 1366284-61-8 N-(2,2-difluoro-3-oxo-1,3-diphenylpropyl)biphenyl-4-carbohydrazide 
• 852-38-0 2-biphenyl-4-yl-5-phenyl-[1,3,4]oxadiazole 

Relevant articles and documents

Synthesis and anti-inflammatory activity of some novel biphenyl-4- carboxylic acid 5-(arylidene)-2-(aryl)-4-oxothiazolidin-3-yl amides

Some new biphenyl-4-carboxylic acid 5-(arylidene)-2-(aryl)-4- oxothiazolidin-3-yl amides have been synthesized and evaluated for anti-inflammatory activity. Biphenyl-4-carboxylic acid hydrazide was converted to the corresponding aryl hydrazones using aryl aldehydes in the presence of catalytic amount of glacial acetic acid. The aryl hydrazones on reaction with thioglycolic acid in the presence of anhydrous zinc chloride yielded the biphenyl-4-carboxylic acid 2-(aryl)-4-oxothiazolidin-3-yl amides, which again on reaction with aromatic aldehydes in the presence of anhydrous sodium acetate and glacial acetic acid furnished the title compounds. The structures of all these newly synthesized compounds were confirmed by their analytical and spectral data which were in full agreement with proposed structures. All compounds were screened for anti-inflammatory activity employing carrageenan test at the dose of 10 mg/kg and exhibited significant activities.