852-38-0Relevant articles and documents
Sodium hypochlorite-mediated synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from hydrazides and aldehydes
Paidi, Karuna Raman,Kolli, Murali Krishna,Reddy, Eeda Koti,Pedakotla, Venkata Ramana
, p. 371 - 376 (2020/05/04)
[Figure not available: see fulltext.] A simple and convenient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed. Structurally divergent symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles can be obtained in moderate to high yields via NaOCl-mediated oxidative cyclization of N-acylhydrazones, generated in situ from aliphatic and aromatic hydrazides and aldehydes.
Iodine-catalysed oxidative cyclisation of acylhydrazones to 2,5-substituted 1,3,4-oxadiazoles
Majji, Ganesh,Rout, Saroj Kumar,Guin, Srimanta,Gogoi, Anupal,Patel, Bhisma K.
, p. 5357 - 5362 (2014/01/23)
An environmentally benign synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed starting from N-aroylhydrazones and N-acetylhydrazones at room or ambient temperature using a catalytic quantity of iodine in the presence of an aqueous hydrogen peroxide oxidant.
1,3,4-Oxadiazole formation as traceless release in solid phase organic synthesis
Cesarini, Sara,Colombo, Nicoletta,Pulici, Maurizio,Felder, Eduard R.,Brill, Wolfgang K.-D.
, p. 10223 - 10236 (2007/10/03)
Oxadiazoles were generated upon a dehydrative cyclization reaction with 2-acyl hydrazides bound to the polymeric support via one of their N atoms using TFAA as a dehydration agent.