122372-10-5

Basic information

• Product Name: 2,5-dichloro-4-phenylpyrimidine
• Synonyms: 2,5-dichloro-4-phenylpyrimidine
• CAS NO: 122372-10-5
• Molecular Weight: 225.077
• Mol File: 122372-10-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,5-dichloro-4-phenylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dichloro-4-phenylpyrimidine(122372-10-5)
• EPA Substance Registry System: 2,5-dichloro-4-phenylpyrimidine(122372-10-5)

Safety Data

• Hazardous Substances Data: 122372-10-5(Hazardous Substances Data)

Upstream product

• 960-16-7 tributylphenylstannane 
• 5750-76-5 2,4,5-trichloropyrimidine 
• 98-80-6 phenylboronic acid 

Downstream Products

• 37428-97-0 2,4,5-triphenylpyrimidine 
• 25095-48-1 2,4-diphenylpyrimidine 
• 901311-75-9 5-chloro-2,4-diphenylpyrimidine 

Relevant articles and documents

Microwave-assisted, efficient and regioselective Pd-catalyzed C-phenylation of halopyrimidines

We herein report that flash heating microwave irradiation is a helpful tool in the formation of arylpyrimidines from the corresponding halopyrimidines. The palladium-catalyzed cross-coupling reactions of 2,4-di- and 2,4,5-trihalopyrimidines with phenylboronic acid under the above conditions are described. By use of the appropriate catalyst and the adequate halopyrimidine, good regioselectivity can be achieved in the 2-, 4-, or 5-positions of the heterocycle. In addition, we show that this methodology is ameneable for the stepwise preparation of mono-, di-, and triphenylpyrimidines.