901311-75-9Relevant articles and documents
Microwave-assisted, efficient and regioselective Pd-catalyzed C-phenylation of halopyrimidines
Ceide, Susana Conde,Montalban, Antonio Garrido
, p. 4415 - 4418 (2007/10/03)
We herein report that flash heating microwave irradiation is a helpful tool in the formation of arylpyrimidines from the corresponding halopyrimidines. The palladium-catalyzed cross-coupling reactions of 2,4-di- and 2,4,5-trihalopyrimidines with phenylboronic acid under the above conditions are described. By use of the appropriate catalyst and the adequate halopyrimidine, good regioselectivity can be achieved in the 2-, 4-, or 5-positions of the heterocycle. In addition, we show that this methodology is ameneable for the stepwise preparation of mono-, di-, and triphenylpyrimidines.