1224244-74-9Relevant articles and documents
Acyl radical insertion for the direct formation of new seven-substituted pterin analogs
Pruet, Jeff M.,Robertus, Jon D.,Anslyn, Eric V.
, p. 2539 - 2540 (2010)
A variety of pterin molecules were synthesized via an under-utilized acyl radical insertion, using aldehydes and α-keto esters as the acyl source. These reactions gave complete regiospecificity for the 7-isomer, with reaction times ranging in minutes, often with instantaneous product precipitation. This approach led to the construction of new pterin analogs unaccessible via traditional Friedel-Crafts acylation. The compounds were characterized by NMR spectroscopy and high-resolution mass spectroscopy.
