2236-60-4 Usage
Description
2-Amino-4-hydroxy-1H-pteridine, also known as Pterin, is a yellow-beige crystalline powder with significant roles in the biosynthesis and metabolism of essential compounds such as tetrahydrobiopterin and molybdopterin. These compounds play crucial roles in various biological processes, including the synthesis of neurotransmitters and the function of certain enzymes.
Uses
Used in Pharmaceutical Industry:
2-Amino-4-hydroxy-1H-pteridine is used as a key intermediate for the synthesis of various pharmaceutical compounds, particularly those involved in the treatment of conditions related to neurotransmitter imbalances. Its role in the biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin makes it a valuable component in the development of drugs targeting these pathways.
Used in Research and Development:
In the field of research and development, 2-Amino-4-hydroxy-1H-pteridine serves as an important compound for studying the mechanisms of neurotransmitter synthesis and enzyme function. Its involvement in the biosynthesis of tetrahydrobiopterin and molybdopterin allows scientists to better understand the underlying processes and develop targeted therapies for related conditions.
Used in Diagnostic Applications:
2-Amino-4-hydroxy-1H-pteridine can be utilized in the development of diagnostic tools and tests, particularly those related to the assessment of neurotransmitter levels and enzyme function. Its role in the biosynthesis of tetrahydrobiopterin and molybdopterin makes it a valuable marker for monitoring the health of these pathways and identifying potential imbalances or dysfunctions.
Used in Nutritional Supplements:
Due to its involvement in the biosynthesis of essential compounds, 2-Amino-4-hydroxy-1H-pteridine may also find application in the development of nutritional supplements aimed at supporting neurotransmitter synthesis and overall brain health. These supplements could potentially help individuals maintain optimal cognitive function and address any deficiencies in these critical pathways.
Purification Methods
It is dissolved in hot 1% aqueous ammonia, filtered, and an equal volume of hot 1M aqueous formic acid is added. The solution is allowed to cool at 0-2o overnight. The solid is collected and washed with distilled water several times by centrifugation and dried in vacuo over P2O5 overnight, and then at 100o overnight (any ammonium formate in the sample evaporates off). [Beilstein 26 III/IV 3936.]
Check Digit Verification of cas no
The CAS Registry Mumber 2236-60-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,3 and 6 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2236-60:
(6*2)+(5*2)+(4*3)+(3*6)+(2*6)+(1*0)=64
64 % 10 = 4
So 2236-60-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H7N5O/c7-6-10-4-3(5(12)11-6)8-1-2-9-4/h1-2,8H,(H4,7,9,10,11,12)
2236-60-4Relevant articles and documents
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Viscontini,Provenzale
, p. 1225 (1969)
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Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer Immunotherapy
Wang, Zhisong,Gao, Yan,He, Lei,Sun, Shuhao,Xia, Tingting,Hu, Lu,Yao, Licheng,Wang, Liangliang,Li, Dan,Shi, Hui,Liao, Xuebin
supporting information, p. 7507 - 7532 (2021/06/28)
Activation of the toll-like receptors 7 and 8 has emerged as a promising strategy for cancer immunotherapy. Herein, we report the design and synthesis of a series of pyrido[3,2-d]pyrimidine-based toll-like receptor 7/8 dual agonists that exhibited potent and near-equivalent agonistic activities toward TLR7 and TLR8. In vitro, compounds 24e and 25a significantly induced the secretion of IFN-α, IFN-γ, TNF-α, IL-1β, IL-12p40, and IP-10 in human peripheral blood mononuclear cell assays. In vivo, compounds 24e, 24m, and 25a significantly suppressed tumor growth in CT26 tumor-bearing mice by remodeling the tumor microenvironment. Additionally, compounds 24e, 24m, and 25a markedly improved the antitumor activity of PD-1/PD-L1 blockade. In particular, compound 24e combined with the anti-PD-L1 antibody led to complete tumor regression. These results demonstrated that TLR7/8 agonists (24e, 24m, and 25a) held great potential as single agents or in combination with PD-1/PD-L1 blockade for cancer immunotherapy.
7-Substituted pterins provide a new direction for ricin A chain inhibitors
Pruet, Jeff M.,Jasheway, Karl R.,Manzano, Lawrence A.,Bai, Yan,Anslyn, Eric V.,Robertus, Jon D.
experimental part, p. 3608 - 3615 (2011/11/01)
Ricin is a potent toxin found in castor seeds. The A chain, RTA, enzymaticlly depurinates a specific adenosine in ribosomal RNA, inhibiting protein synthesis. Ricin is a known chemical weapons threat having no effective antidote. This makes the discovery of new inhibitors of great importance. We have previously used 6-substituted pterins, such as pteroic acid, as an inhibitor platform with moderate success. We now report the success of 7-carboxy pterin (7CP) as an RTA inhibitor; its binding has been monitored using both kinetic and temperature shift assays and by X-ray crystallography. We also discuss the synthesis of various derivatives of 7CP, and their binding affinity and inhibitory effects, as part of a program to make effective RTA inhibitors.
