487-21-8 Usage
Description
Lumazine, also known as a 2,4-dihydroxypteridine, is a light yellow to ochre powder with unique chemical properties. It is a pteridine derivative that plays a significant role in various applications across different industries due to its distinctive characteristics.
Uses
Used in Analytical Chemistry:
Lumazine is used as a new MALDI (Matrix-Assisted Laser Desorption/Ionization) matrix for the analysis of complex (phospho)lipid mixtures. Its ability to enhance the ionization process and improve the detection of these mixtures makes it a valuable tool in the field of analytical chemistry, particularly for researchers studying lipid biochemistry and related areas.
Used in Pharmaceutical Industry:
Lumazine, due to its chemical properties, can be utilized in the development of pharmaceutical compounds. Its potential applications in drug discovery and design can contribute to the creation of novel therapeutic agents, targeting various health conditions and diseases.
Used in Research and Development:
In the realm of research and development, Lumazine can be employed as a key component in the synthesis of other bioactive molecules or as a starting material for the development of new chemical entities with potential applications in various fields, including medicine, agriculture, and environmental science.
Purification Methods
Crystallise the dione from water. It has also been purified as for pterin below. [Dallacker & Steiner Justus Liebigs Ann Chem 660 98 1962, Beilstein 26 III/IV 2489.]
Check Digit Verification of cas no
The CAS Registry Mumber 487-21-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 7 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 487-21:
(5*4)+(4*8)+(3*7)+(2*2)+(1*1)=78
78 % 10 = 8
So 487-21-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H4N4O2/c11-5-3-4(8-2-1-7-3)9-6(12)10-5/h1-2H,(H2,8,9,10,11,12)
487-21-8Relevant articles and documents
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Norrestam et al.
, p. 659,663 (1972)
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Ionic liquid promoted synthesis of heterocycle-fused pyrimidine-2,4(1H,3H)-diones utilising CO2
Li, Chun,Lu, Xunhua,Yang, Yuanyong,Yang, Shenggang,Zhang, Lin
supporting information, p. 2463 - 2466 (2018/05/26)
An efficient ionic liquid system was developed for the preparation of various heterocycle-fused pyrimidine-2, 4(1H,3H)-diones in moderate to excellent yields (52–95%). It was found that [HDBN+][TFE?], a simple and easily prepared ionic liquid, could act as both the solvent and reaction promoter, and that the reactions could be efficiently carried out at atmospheric pressures of CO2.
One-step synthesis of lumazine and xanthine: First co-crystal of lumazine and perchloric acid with a unique monohydrated hydronium ion (H 5O2+) mediated supramolecular assembly of the lumazine dimer
Goswami, Shyamaprosad,Maity, Annada C.,Fun, Hoong-Kun
, p. 4056 - 4064 (2008/02/13)
A perchloric acid mediated one-step synthesis of lumazine derivatives from pterins and xanthine from guanine is reported. However, 2-pivaloylamino derivatives of pterins underwent simple hydrolysis of the pivaloylamino group generating free pterin compounds, but the 2-oxo derivatives, that is, the lumazine compounds, were not obtained. A novel supramolecular assembly is constructed by the unique hydrogen bonding of H5O2 + bridging two hydrogen-bonded dimers of lumazine to form the co-crystal 21 with aqueous perchloric acid. In contrast, N2-pivaloyl- 6-bromo-5-deazapterin was simply hydrolysed to form the protonated deazapterin 22, which forms a unique six-membered cyclic hydrogen-bonded structure leading to the generation of a polymeric supramolecular assembly. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
