1225592-37-9

Basic information

• Product Name: [4-chloro-2-(4-chlorobenzoyl)phenoxy]acetonitrile
• CAS NO: 1225592-37-9
• Molecular Weight: 306.148
• Mol File: 1225592-37-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [4-chloro-2-(4-chlorobenzoyl)phenoxy]acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: [4-chloro-2-(4-chlorobenzoyl)phenoxy]acetonitrile(1225592-37-9)
• EPA Substance Registry System: [4-chloro-2-(4-chlorobenzoyl)phenoxy]acetonitrile(1225592-37-9)

Safety Data

• Hazardous Substances Data: 1225592-37-9(Hazardous Substances Data)

Upstream product

• 107-14-2 chloroacetonitrile 
• 61785-37-3 (5-chloro-2-hydroxy-phenyl)-(4-chloro-phenyl)-methanone 

Downstream Products

• 1225592-45-9 2-[4-chloro-2-(4-chlorobenzoyl)phenoxy]ethanethioamide 

Relevant articles and documents

Synthesis of some novel 2-[2-(aroyl-aroxy)-methyl]-4-phenyl-1,3-thiazoles as potent anti-inflammatory agents: Research letter

A series of 2-[2-(aroyl-aroxy)-methyl]-4-phenyl-1,3-thiazoles 4a-j were obtained via multiple step synthesis sequence beginning with the hydroxybenzophenones (1a-g). Hydroxybenzophenones on reaction with chloroacetonitrile affords [(2-benzoyl) phenoxy] acetonitrile (2a-g), which reacts with H2S/NH4OH and yields [(2-benzoyl) phenoxy] acetothiamide (3a-g), which on treatment with phenacylbromides affords 2-[2-(aroyl-aroxy)-methyl]-4-phenyl-1,3-thiazoles (4a-j). All the newly synthesized compounds were evaluated for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, (4g), compounds with chloro substituents showed more potent activity than the standard drug phenyl butazone at all doses tested.