61785-37-3

Basic information

• Product Name: Methanone, (5-chloro-2-hydroxyphenyl)(4-chlorophenyl)-
• CAS NO: 61785-37-3
• Molecular Formula: C13H8Cl2O2
• Molecular Weight: 267.111
• Mol File: 61785-37-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Methanone, (5-chloro-2-hydroxyphenyl)(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (5-chloro-2-hydroxyphenyl)(4-chlorophenyl)-(61785-37-3)
• EPA Substance Registry System: Methanone, (5-chloro-2-hydroxyphenyl)(4-chlorophenyl)-(61785-37-3)

Safety Data

• Hazardous Substances Data: 61785-37-3(Hazardous Substances Data)

Upstream product

• 122-01-0 4-chloro-benzoyl chloride 
• 6961-42-8 4-chlorophenyl 4-chlorobenzoate 

Downstream Products

• 35445-77-3 4-chloro-2-((4-chlorophenyl)(hydroxy)methyl)phenol 
• 1225592-37-9 [4-chloro-2-(4-chlorobenzoyl)phenoxy]acetonitrile 
• 1186436-48-5 [5-chloro-2-(4-nitro-benzyloxy)-phenyl] (4-chloro-phenyl) methanone 
• 1059685-93-6 C₁₉H₁₄Cl₂N₂O₄ 

Relevant articles and documents

Preparation of benzoyloxy benzophenone derivatives and their inhibitory effects of ICAM-1 expression

Benzoyloxy benzophenone derivatives were prepared in 3 steps including DCC coupling, Fries rearrangement and esterification from benzoic acids in 24-89% total yields. Among the prepared 12 benzophenone analogues 1a-1l, the compound 1b having three chloro groups at the para position showed maximum inhibitory effects of ICAM-1 expression but, 1a which have no substituents at all showed no inhibitory activity. This study provides the evidences that benzoyloxy benzophenone derivative, 1b may exert its anti-inflammatory activity by suppressing IFN-γ-induced ICAM-1 expression.

Synthesis and crystal structure of [5-chloro-2-(4-nitrobenzyloxy)-phenyl]- (4-chloro-phenyl) methanone

The title compound, C20H13Cl2NO 4, crystallizes in the monoclinic crystal system and space group P21/n with cell parameters a = 9.434(2) A, b = 13.167(3) A, c = 15.087(4) A, β = 105.289(8)°, V = 1807.