1227626-89-2

Basic information

• Product Name: N-(2,2-diethoxyethyl)-N-((1,4-dimethyl-9H-carbazol-3-yl)methyl)-2-nitrobenzenesulfonamide
• Synonyms: N-(2,2-diethoxyethyl)-N-((1,4-dimethyl-9H-carbazol-3-yl)methyl)-2-nitrobenzenesulfonamide
• CAS NO: 1227626-89-2
• Molecular Weight: 525.626
• Mol File: 1227626-89-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(2,2-diethoxyethyl)-N-((1,4-dimethyl-9H-carbazol-3-yl)methyl)-2-nitrobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,2-diethoxyethyl)-N-((1,4-dimethyl-9H-carbazol-3-yl)methyl)-2-nitrobenzenesulfonamide(1227626-89-2)
• EPA Substance Registry System: N-(2,2-diethoxyethyl)-N-((1,4-dimethyl-9H-carbazol-3-yl)methyl)-2-nitrobenzenesulfonamide(1227626-89-2)

Safety Data

• Hazardous Substances Data: 1227626-89-2(Hazardous Substances Data)

Upstream product

• 65266-47-9 N-(1,4-dimethylcarbazol-3-ylmethyl) aminoacetaldehyde diethyl acetal 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 14501-66-7 1,4-dimethylcarbazole-3-carboxaldehyde 
• 645-36-3 2,2-diethoxy-ethanamine 

Downstream Products

• 519-23-3 ellipticine 
• 51131-85-2 9-hydroxyellipticine 

Relevant articles and documents

Synthesis and in vitro antitumor activity of 9-hydroxyellipticine derivatives with glucose conjugation via triazolylmethyl succinate linker

Three types of novel 9-hydroxyellipticine derivatives 7a-c with glucose conjugation, linked by a triazolylmethyl succinic ester bond, were synthesized, and their cytotoxicity against HeLa S-3 and 293T cells was evaluated together with ellipticine (1) and 9-hydroxyellipticine (3). These new compounds 7a-c exhibited potent antitumor activity against HeLa S-3 and 293T, and water solubility of 7a was greatly higher than those of 1 and 3. The effects of an -OCH2CH2-spacer and the amino sugar moiety on the antitumor activity were examined using 7b,c. Furthermore, one of these glucose-conjugates 7a was applied to hydrolysis, catalyzed by carboxyesterase, leading to the formation of 3 under physiological conditions.