1228456-31-2

Basic information

• Product Name: p-nitrophenyl 2-phenylpentanoate
• Synonyms: p-nitrophenyl 2-phenylpentanoate
• CAS NO: 1228456-31-2
• Molecular Weight: 299.326
• Mol File: 1228456-31-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: p-nitrophenyl 2-phenylpentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: p-nitrophenyl 2-phenylpentanoate(1228456-31-2)
• EPA Substance Registry System: p-nitrophenyl 2-phenylpentanoate(1228456-31-2)

Safety Data

• Hazardous Substances Data: 1228456-31-2(Hazardous Substances Data)

Upstream product

• 7782-21-0 (RS)-2-phenylpentanoic acid 
• 7693-46-1 4-Nitrophenyl chloroformate 

Downstream Products

• 100-02-7 4-nitro-phenol 
• 7782-25-4 (S)-(+)-2-phenylvaleric acid 
• 7782-27-6 (R)-2-phenylpentanoic acid 

Relevant articles and documents

Directed evolution of an enantioselective lipase with broad substrate scope for hydrolysis of α-substituted esters

A variant of Candida antarctica lipase A (CalA) was developed for the hydrolysis of α-substituted p-nitrophenyl esters by directed evolution. The E values of this variant for 7 different esters was 45-276, which is a large improvement compared to 2-20 for the wild type. The broad substrate scope of this enzyme variant is of synthetic use, and hydrolysis of the tested substrates proceeded with an enantiomeric excess between 95-99%. A 30-fold increase in activity was also observed for most substrates. The developed enzyme variant shows (R)-selectivity, which is reversed compared to the wild type that is (S)-selective for most substrates.