7782-25-4

Basic information

• Product Name: (S)-(+)-2-phenylvaleric acid
• Synonyms: (S)-(+)-2-phenylvaleric acid
• CAS NO: 7782-25-4
• Molecular Weight: 178.231
• Mol File: 7782-25-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (S)-(+)-2-phenylvaleric acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-2-phenylvaleric acid(7782-25-4)
• EPA Substance Registry System: (S)-(+)-2-phenylvaleric acid(7782-25-4)

Safety Data

• Hazardous Substances Data: 7782-25-4(Hazardous Substances Data)

Upstream product

• 1575-70-8 (S)-2-phenyl-4-pentenoic acid 
• 26382-04-7 diisopropyl-carbamic acid phenylmethyl ester 
• 100-51-6 benzyl alcohol 
• 124-38-9 carbon dioxide 
• 84473-31-4 4-(Bromobutyl)benzene 
• 1228456-31-2 p-nitrophenyl 2-phenylpentanoate 
• 7782-21-0 (RS)-2-phenylpentanoic acid 
• 5558-78-1 2-phenyl-pentanenitrile 
• 14387-51-0 2-phenyl-2-propyl acetamide 

Downstream Products

• 6306-30-5 (S)-3-phenyl-hexan-2-one 
• 132515-10-7 (S)-4-phenylheptan-3-one 
• 19986-16-4 (S)-2-cyclohexyl-valeric acid 
• 211230-01-2 D-2-phenyl-valeronitrile 

Relevant articles and documents

Introduction of single mutation changes arylmalonate decarboxylase to racemase

The introduction of only one mutation based on the estimated reaction mechanism endowed arylmalonate decarboxylase with a racemase activity, which catalyses racemisation of α-arylpropionates. The Royal Society of Chemistry 2006.

Enantiospecific, regioselective cross-coupling reactions of secondary allylic boronic esters

An original syn: The first enantioselective Suzuki-Miyaura cross-coupling of chiral, enantioenriched secondary allylic boronic esters is described (see scheme; DME=dimethoxyethane, Bpin = pinacolboryl, dba = dibenzylideneacetone). Mechanistic studies show that the reactions proceed via γ-selective transmetalation followed by reductive elimination. The reaction provides the first independent confirmation that the transmetalation of boronic esters proceeds via a syn pathway. Copyright

Enantiopure tert-butyl(phenyl)phosphine oxide. Chirality-recognition ability and mechanism

When enantiopure tert-butyl(phenyl)phosphine oxide 1 was used as a resolving agent, it showed an acceptable to good chirality-recognition ability for several kinds of racemic carboxylic acids 2. A study on a chirality-recognition mechanism based on X-ray crystallographic analyses of the diastereomeric complexes of 2 with 1 revealed that the complex crystals consisted of helical columns and that 1 was not responsible for the formation of the helical column and occupied a void between the columns; although 1 interacted with 2 via a hydrogen bond to primarily form a pair with 2, the complex crystals were mainly stabilized by the accumulation of weak interactions, such as CH/π, π/π and CH...O interactions, between 1/1, 1/2 and 2/2.