19986-16-4Relevant articles and documents
Palladium-Catalyzed Site-Selective Fluorination of Unactivated C(sp3)-H Bonds
Miao, Jinmin,Yang, Ke,Kurek, Martin,Ge, Haibo
, p. 3738 - 3741 (2015/08/18)
The transition-metal-catalyzed direct C-H bond fluorination is an attractive synthetic tool toward the preparation of organofluorines. While many methods exist for the direct sp3 C-H functionalization, site-selective fluorination of unactivated sp3 carbons remains a challenge. Direct, highly site-selective and diastereoselective fluorination of aliphatic amides via a palladium-catalyzed bidentate ligand-directed C-H bond functionalization process on unactivated sp3 carbons is reported. With this approach, a wide variety of β-fluorinated amino acid derivatives and aliphatic amides, important motifs in medicinal and agricultural chemistry, were prepared with palladium acetate as the catalyst and Selectfluor as the fluorine source.
