122853-32-1Relevant articles and documents
Concise Synthesis of (±)-Clopidogrel via Carboxylation of Benzylamine with CO2
Venkataramasubramanian,Sudalai, Arumugam
, p. 2099 - 2105 (2015)
A concise and efficient synthesis of (±)-clopidogrel, an antithrombotic agent, is achieved by inserting CO2 at the benzylic position as the key reaction without using any toxic transition metals. The overall yield of the synthetic process is 38% and the salient features include operationally simple process chemistry and fewer steps.